Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects

E. Mariani, F. Mangialasche, F. T. Feliziani, R. Cecchetti, M. Malavolta, P. Bastiani, M. Baglioni, G. Dedoussis, T. Fulop, G. Herbein, J. Jajte, D. Monti, L. Rink, E. Mocchegiani, P. Mecocci

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

A large body of experimental research indicates that oxidative stress contributes to the processes related to aging and age-related diseases. Trace elements, particularly zinc (Zn), are essential components of the endogenous enzymatic antioxidant defenses. The aim of this study was to determine the activity of three main antioxidant enzymes in plasma [i.e. superoxide dismutase (pSOD), catalase (CAT), glutathione peroxidase (GPx)] and of SOD in erythrocyte (eSOD) in a group of 1108 healthy elderly subjects from different European countries. The same enzymatic activities were evaluated in a subgroup of 108 subjects before and after Zn supplementation. We observed that eSOD activity increased with age, whereas plasma Zn decreased. Moreover, we found that women showed higher eSOD activity and lower plasma Zn compared to men. There were no age and gender-related differences in the activities of pSOD, CAT and GPx. After Zn supplementation, the activities of Zn-dependent enzymes (pSOD and eSOD), as well as plasma Zn concentration, were significantly higher than before supplementation. These results were not influenced by age, gender, plasma Zn variations (Δ Zn) and geographic area. These data suggest the potential beneficial effects of Zn supplementation on Zn-dependent antioxidant enzymes in healthy elderly subjects.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalExperimental Gerontology
Volume43
Issue number5
DOIs
Publication statusPublished - May 2008

Fingerprint

Enzyme activity
Zinc
Healthy Volunteers
Antioxidants
Enzymes
Plasmas
Superoxide Dismutase
Glutathione Peroxidase
Catalase
Oxidative stress
Trace Elements
Oxidative Stress
Aging of materials
Erythrocytes

Keywords

  • Aging
  • Catalase
  • Glutathione peroxidase
  • Oxidative stress
  • Superoxide dismutase
  • Zinc status
  • Zinc supplementation

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

Mariani, E., Mangialasche, F., Feliziani, F. T., Cecchetti, R., Malavolta, M., Bastiani, P., ... Mecocci, P. (2008). Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects. Experimental Gerontology, 43(5), 445-451. https://doi.org/10.1016/j.exger.2007.10.012

Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects. / Mariani, E.; Mangialasche, F.; Feliziani, F. T.; Cecchetti, R.; Malavolta, M.; Bastiani, P.; Baglioni, M.; Dedoussis, G.; Fulop, T.; Herbein, G.; Jajte, J.; Monti, D.; Rink, L.; Mocchegiani, E.; Mecocci, P.

In: Experimental Gerontology, Vol. 43, No. 5, 05.2008, p. 445-451.

Research output: Contribution to journalArticle

Mariani, E, Mangialasche, F, Feliziani, FT, Cecchetti, R, Malavolta, M, Bastiani, P, Baglioni, M, Dedoussis, G, Fulop, T, Herbein, G, Jajte, J, Monti, D, Rink, L, Mocchegiani, E & Mecocci, P 2008, 'Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects', Experimental Gerontology, vol. 43, no. 5, pp. 445-451. https://doi.org/10.1016/j.exger.2007.10.012
Mariani, E. ; Mangialasche, F. ; Feliziani, F. T. ; Cecchetti, R. ; Malavolta, M. ; Bastiani, P. ; Baglioni, M. ; Dedoussis, G. ; Fulop, T. ; Herbein, G. ; Jajte, J. ; Monti, D. ; Rink, L. ; Mocchegiani, E. ; Mecocci, P. / Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects. In: Experimental Gerontology. 2008 ; Vol. 43, No. 5. pp. 445-451.
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