Effetti della zonisamide sulle funzioni cognitive in pazienti affetti da epilessia focale farmacoresistente

Translated title of the contribution: Effects of zonisamide on cognitive functions in patients with refractory focal epilepsy

M. Mitolo, M. Tursi, M. Ladogana, G. Boero, P. Lamberti, A. La Neve, M. F. De Caro

Research output: Contribution to journalArticle

Abstract

Objective: to evaluate the influence of zonisamide (ZNS) as add-on therapy on cognitive functions in patients with Refractory Focal Epilepsy. Methods: subjects were affected by Focal Epilepsy refractory to at least two previous antiepileptic drugs. After three months baseline period at stable therapy, ZNS were titrated, as adjunctive therapy, up to 300 mg/day in 8 weeks. All patients underwent a neuropsychological battery test at two points: prior to titration and 24 weeks after reaching 300 mg/day dosage of ZNS. Results: we report the preliminary results of the first 10 patients enrolled (4 M; mean age 48+10 yrs; mean educational 7.9+3.7 yrs); ZNS was added to 1 AED in 7 patients and to > 1 AED in 3. After ZNS therapy we observed in neuropsychological tests a significant (p = 0,015) worsening of performance in FLUS (Baseline: 31 + 6,23; T1:26,2 + 3,76). Conclusions: this pilot study shows a good tolerability of ZNS on cognitive performance with no significant changes apart from phonemic and semantic fluency.

Translated title of the contributionEffects of zonisamide on cognitive functions in patients with refractory focal epilepsy
Original languageItalian
Pages (from-to)62-64
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number140
Publication statusPublished - Apr 2010

ASJC Scopus subject areas

  • Clinical Neurology

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