Abstract
To evaluate the influence of atropine on atrial refractoriness and its dispersions, we studied ten subjects with sinus bradycardia who were otherwise healthy. Effective and functional refractory periods were measured at three sites of the right atrium (high, middle, and low in the lateral wall), in sinus rhythm and during atrial pacing (120/min), before and after i.v. administration of 0.04 mg/kg of atropine. Both before and after administration, dispersion of atrial refractoriness was determined from the range of refractory periods measured at the three atrial sites as the longest minus the shortest refractory period. Our data indicate that atropine was able to significantly reduce refractoriness and its dispersion. The study protocol allowed us to exclude the possibility that cycle length played a role. The antivagal effect of atropine seemed to explain our findings, even if the possibility that the drug had a direct effect could not be excluded.
| Original language | English |
|---|---|
| Pages (from-to) | 254-258 |
| Number of pages | 5 |
| Journal | International Journal of Clinical Pharmacology Therapy and Toxicology |
| Volume | 22 |
| Issue number | 5 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)
Cite this
Effects on atropine on atrial refractoriness and its dispersion in humans. / Michelucci, A.; Padeletti, L.; Fradella, G. A.; Molina Lova, R.; Monizzi, D.; Giomi, A.; Fantini, F.
In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 22, No. 5, 1984, p. 254-258.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects on atropine on atrial refractoriness and its dispersion in humans
AU - Michelucci, A.
AU - Padeletti, L.
AU - Fradella, G. A.
AU - Molina Lova, R.
AU - Monizzi, D.
AU - Giomi, A.
AU - Fantini, F.
PY - 1984
Y1 - 1984
N2 - To evaluate the influence of atropine on atrial refractoriness and its dispersions, we studied ten subjects with sinus bradycardia who were otherwise healthy. Effective and functional refractory periods were measured at three sites of the right atrium (high, middle, and low in the lateral wall), in sinus rhythm and during atrial pacing (120/min), before and after i.v. administration of 0.04 mg/kg of atropine. Both before and after administration, dispersion of atrial refractoriness was determined from the range of refractory periods measured at the three atrial sites as the longest minus the shortest refractory period. Our data indicate that atropine was able to significantly reduce refractoriness and its dispersion. The study protocol allowed us to exclude the possibility that cycle length played a role. The antivagal effect of atropine seemed to explain our findings, even if the possibility that the drug had a direct effect could not be excluded.
AB - To evaluate the influence of atropine on atrial refractoriness and its dispersions, we studied ten subjects with sinus bradycardia who were otherwise healthy. Effective and functional refractory periods were measured at three sites of the right atrium (high, middle, and low in the lateral wall), in sinus rhythm and during atrial pacing (120/min), before and after i.v. administration of 0.04 mg/kg of atropine. Both before and after administration, dispersion of atrial refractoriness was determined from the range of refractory periods measured at the three atrial sites as the longest minus the shortest refractory period. Our data indicate that atropine was able to significantly reduce refractoriness and its dispersion. The study protocol allowed us to exclude the possibility that cycle length played a role. The antivagal effect of atropine seemed to explain our findings, even if the possibility that the drug had a direct effect could not be excluded.
UR - http://www.scopus.com/inward/record.url?scp=0021349993&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021349993&partnerID=8YFLogxK
M3 - Article
C2 - 6746148
AN - SCOPUS:0021349993
VL - 22
SP - 254
EP - 258
JO - International Journal of Clinical Pharmacology and Therapeutics
JF - International Journal of Clinical Pharmacology and Therapeutics
SN - 0174-4879
IS - 5
ER -