Effects on cimetidine bioavailability of metoclopramide and antacids given two hours apart

N. Barzaghi, F. Crema, G. Mescoli, E. Perucca

Research output: Contribution to journalArticle

Abstract

Plasma cimetidine levels were determined in 9 normal subjects after a single oral dose of cimetidine 400 mg under control conditions, 2 h before metoclopramide 20 mg and 2 h after a potent antacid. The bioavailability of cimetidine was not significantly affected by metoclopramide and it was marginally reduced by the antacid.

Original languageEnglish
Pages (from-to)409-410
Number of pages2
JournalEuropean Journal of Clinical Pharmacology
Volume37
Issue number4
DOIs
Publication statusPublished - Jul 1989

Keywords

  • absorption
  • antacids
  • bioavailability
  • cimetidine
  • drug interaction
  • metoclopramide

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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