Advantages and disadvantages of jejunal or colonic segments as esophageal substitutes have been repeatedly stressed. This experimental study investigated a still unknown property of the transposed jejunal or colonic mucosa: the effects of the intestinal implant on antral G cells. Forty Wistar rats underwent transposition of jejunal or colonic patches to the pyloric antrum or the upper portion of the gastric body. Ten further animals were used as controls. Serum gastrin values were weekly determined in fasted (24 hours) and freely fed rats using radioimmunoassay, 3 months after surgery. Antral G cell density was assessed using the immunoperoxidase method. Basal serum gastrin levels and antral G cell density were increased following colonic mucosa transposition to the pyloric antrum, while not after jejunal mucosa grafting. No significant differences among serum gastrin values in freely fed rats were found. A significant correlation between the topographic location of the colonic patch on the stomach and the degree of G cell proliferation was documented. In conclusion, potential advantages in favour of jejunal interposition for the treatment of reflux stenosis of the esophagus would include the lack of antral G cell stimulation.
|Translated title of the contribution||Effects on gastrin incretion of the transposition of jejunal and colic segments at the level of the upper digestive tract|
|Number of pages||5|
|Publication status||Published - 1992|
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