TY - JOUR
T1 - Effects on membrane lung gas exchange of an intermittent high gas flow recruitment maneuver
T2 - preliminary data in veno-venous ECMO patients
AU - Castagna, Luigi
AU - Zanella, Alberto
AU - Scaravilli, Vittorio
AU - Magni, Federico
AU - Deab, Salua Abd El Aziz El Sayed
AU - Introna, Michele
AU - Mojoli, Francesco
AU - Grasselli, Giacomo
AU - Pesenti, Antonio
AU - Patroniti, Nicolò
PY - 2015/9/4
Y1 - 2015/9/4
N2 - Gas exchange capabilities of polymethylpentene membrane lungs (MLs) worsen over time. ML deterioration is related to protein deposit and clot formation. Condensation and trapping of water vapor inside ML hollow fibers might affect ML performances as well. Increasing sweep gas flow (GF) could remove such fluid. The purpose of this study was to evaluate the effects on ML gas exchange of a recruitment maneuver (RM) based on a brief increase in GF, during veno-venous ECMO support. Short-term (15 min) effects of 20 RMs were assessed. RM raised ML CO2 removal from 149 ± 37 to 174 ± 41 ml/min (p 2 transfer (155 ± 31 and 158 ± 31 ml/min before and after RM, respectively). ML outlet pCO2 decreased after RM from 51.2 ± 5.8 to 45.8 ± 5.4 mmHg (p 2 increased from 520 ± 61 to 555 ± 51 mmHg (p 2 removal substantially, albeit temporarily. ML oxygenation performance was marginally affected.
AB - Gas exchange capabilities of polymethylpentene membrane lungs (MLs) worsen over time. ML deterioration is related to protein deposit and clot formation. Condensation and trapping of water vapor inside ML hollow fibers might affect ML performances as well. Increasing sweep gas flow (GF) could remove such fluid. The purpose of this study was to evaluate the effects on ML gas exchange of a recruitment maneuver (RM) based on a brief increase in GF, during veno-venous ECMO support. Short-term (15 min) effects of 20 RMs were assessed. RM raised ML CO2 removal from 149 ± 37 to 174 ± 41 ml/min (p 2 transfer (155 ± 31 and 158 ± 31 ml/min before and after RM, respectively). ML outlet pCO2 decreased after RM from 51.2 ± 5.8 to 45.8 ± 5.4 mmHg (p 2 increased from 520 ± 61 to 555 ± 51 mmHg (p 2 removal substantially, albeit temporarily. ML oxygenation performance was marginally affected.
KW - Extracorporeal membrane oxygenation
KW - Insensible
KW - Oxygenators
KW - Respiratory dead space
KW - Water loss
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U2 - 10.1007/s10047-015-0831-3
DO - 10.1007/s10047-015-0831-3
M3 - Article
C2 - 25809452
AN - SCOPUS:84940722499
VL - 18
SP - 213
EP - 219
JO - Journal of Artificial Organs
JF - Journal of Artificial Organs
SN - 1434-7229
IS - 3
ER -