Effects on platelet function by human interferon-beta in carcinoma patients

P. Ferroni, M. Roselli, A. Diodati, C. U. Casciani, P. P. Gazzaniga

Research output: Contribution to journalArticle

Abstract

The effects of a therapeutic course of human interferon-β (Hu IFN-β) on platelet function were evaluated in 10 patients with neoplatstic disorder. Each patient received, by intramuscular route, 6 x 106 IU of Hu IFN-β every other day for 2 weeks. Platelet count, packed platelet volume, platelet size and in vitro aggregation tests were evaluated before IFN treatment and weekly during the treatment. An overall increase of in vitro platelet aggregation was present in all patients after the first week, and persisted after the second week of treatment. This effect was most pronounced when ADP and collagen were used as aggregation inducers. No significant differences were observed in IFN-γ, IL-6, IL-1β and GM-CSF serum levels before and after IFN-β treatment; nevertheless a parallel rise in IL-1β and/or GM-CSF and platelet count was noticed. The results obtained indicate that the effects of IFN-β on platelet function are most likely due to a direct influence on bone marrow.

Original languageEnglish
Pages (from-to)2779-2784
Number of pages6
JournalAnticancer Research
Volume14
Issue number6 B
Publication statusPublished - 1994

Fingerprint

Interferon-beta
Blood Platelets
Carcinoma
Granulocyte-Macrophage Colony-Stimulating Factor
Platelet Count
Interleukin-1
Interferons
Therapeutic Uses
Therapeutics
Platelet Aggregation
Adenosine Diphosphate
Interleukin-6
Collagen
Bone Marrow
Serum
In Vitro Techniques

Keywords

  • Blood platelets
  • Cytokines
  • Human interferon-β
  • Platelet aggregation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ferroni, P., Roselli, M., Diodati, A., Casciani, C. U., & Gazzaniga, P. P. (1994). Effects on platelet function by human interferon-beta in carcinoma patients. Anticancer Research, 14(6 B), 2779-2784.

Effects on platelet function by human interferon-beta in carcinoma patients. / Ferroni, P.; Roselli, M.; Diodati, A.; Casciani, C. U.; Gazzaniga, P. P.

In: Anticancer Research, Vol. 14, No. 6 B, 1994, p. 2779-2784.

Research output: Contribution to journalArticle

Ferroni, P, Roselli, M, Diodati, A, Casciani, CU & Gazzaniga, PP 1994, 'Effects on platelet function by human interferon-beta in carcinoma patients', Anticancer Research, vol. 14, no. 6 B, pp. 2779-2784.
Ferroni P, Roselli M, Diodati A, Casciani CU, Gazzaniga PP. Effects on platelet function by human interferon-beta in carcinoma patients. Anticancer Research. 1994;14(6 B):2779-2784.
Ferroni, P. ; Roselli, M. ; Diodati, A. ; Casciani, C. U. ; Gazzaniga, P. P. / Effects on platelet function by human interferon-beta in carcinoma patients. In: Anticancer Research. 1994 ; Vol. 14, No. 6 B. pp. 2779-2784.
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