Abstract
Hormonal-metabolic stress responses have bevond doubt an effect on morbidity/mortality related to surgery. The present study aimed to determine which anaesthetic technique could afford the best protection in children, through analysis of the perioperative Cortisol, prolactin and beta-endorphin plasma levels. Thirty-six young patients 3-10 years old, ASA I-II, scheduled for hypospadias or vesicoureteral reflux surgery of a duration > 60 min, were randomized into three groups (n = 12). Children of group 1 were given initially propofol and fentanyl then isoflurane 1% ; group 2 received TIVA with propofol and fentanyl, group 3 received initially propofol then an epidural lumbar block with bupivacaine 0.25% (single shot) and continuous propofol i.v. infusion. Cortisol, prolactin and beta-endorphin levels increased significantly in group 1 only. No significant differences were observed between groups 2 and 3. Early postoperative analgesia was better in group 3. These data suggest that TIVA and particularly epidural block could afford a better protection against the surgical stress in children submitted to subumbilical operations.
| Original language | French |
|---|---|
| Pages (from-to) | 297-302 |
| Number of pages | 6 |
| Journal | Cahiers d'Anesthesiologie |
| Volume | 44 |
| Issue number | 4 |
| Publication status | Published - 1996 |
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Efficacité protectrice de trois méthodes anesthésiques àl'égard du stress chirurgical chez l'enfant. / Ivani, G.; Vaira, M.; Fossa, S.; Mattioli, G.; Jasonni, V.; Caffarena, P. E.; Podestà, E.; Parodi, E.; Rossi, L.
In: Cahiers d'Anesthesiologie, Vol. 44, No. 4, 1996, p. 297-302.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacité protectrice de trois méthodes anesthésiques àl'égard du stress chirurgical chez l'enfant
AU - Ivani, G.
AU - Vaira, M.
AU - Fossa, S.
AU - Mattioli, G.
AU - Jasonni, V.
AU - Caffarena, P. E.
AU - Podestà, E.
AU - Parodi, E.
AU - Rossi, L.
PY - 1996
Y1 - 1996
N2 - Hormonal-metabolic stress responses have bevond doubt an effect on morbidity/mortality related to surgery. The present study aimed to determine which anaesthetic technique could afford the best protection in children, through analysis of the perioperative Cortisol, prolactin and beta-endorphin plasma levels. Thirty-six young patients 3-10 years old, ASA I-II, scheduled for hypospadias or vesicoureteral reflux surgery of a duration > 60 min, were randomized into three groups (n = 12). Children of group 1 were given initially propofol and fentanyl then isoflurane 1% ; group 2 received TIVA with propofol and fentanyl, group 3 received initially propofol then an epidural lumbar block with bupivacaine 0.25% (single shot) and continuous propofol i.v. infusion. Cortisol, prolactin and beta-endorphin levels increased significantly in group 1 only. No significant differences were observed between groups 2 and 3. Early postoperative analgesia was better in group 3. These data suggest that TIVA and particularly epidural block could afford a better protection against the surgical stress in children submitted to subumbilical operations.
AB - Hormonal-metabolic stress responses have bevond doubt an effect on morbidity/mortality related to surgery. The present study aimed to determine which anaesthetic technique could afford the best protection in children, through analysis of the perioperative Cortisol, prolactin and beta-endorphin plasma levels. Thirty-six young patients 3-10 years old, ASA I-II, scheduled for hypospadias or vesicoureteral reflux surgery of a duration > 60 min, were randomized into three groups (n = 12). Children of group 1 were given initially propofol and fentanyl then isoflurane 1% ; group 2 received TIVA with propofol and fentanyl, group 3 received initially propofol then an epidural lumbar block with bupivacaine 0.25% (single shot) and continuous propofol i.v. infusion. Cortisol, prolactin and beta-endorphin levels increased significantly in group 1 only. No significant differences were observed between groups 2 and 3. Early postoperative analgesia was better in group 3. These data suggest that TIVA and particularly epidural block could afford a better protection against the surgical stress in children submitted to subumbilical operations.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029820293&partnerID=8YFLogxK
M3 - Articolo
C2 - 9033826
AN - SCOPUS:0029820293
VL - 44
SP - 297
EP - 302
JO - Cahiers d'Anesthesiologie
JF - Cahiers d'Anesthesiologie
SN - 0079-7625
IS - 4
ER -