TY - JOUR
T1 - Efficacy, adherence and tolerability of once daily tenofovir DF-containing antiretroviral therapy in former injecting drug users with HIV-1 receiving opiate treatment
T2 - Results of a 48-week open-label study
AU - Esser, Stefan
AU - Haberl, A.
AU - Mulcahy, F.
AU - Gölz, J.
AU - Lazzarin, A.
AU - Teofilo, E.
AU - Vera, J.
AU - Körber, A.
AU - Staszewski, S.
PY - 2011/10/10
Y1 - 2011/10/10
N2 - Objective: To assess efficacy, adherence and tolerability of once daily antiretroviral therapy containing tenofovir disoproxil fumarate (DF) 300 mg in HIV-1-infected former injecting drug users receiving opiate treatment (IVDU). Methods: European, 48-week, open-label, single-arm, multicenter study. Patients were either antiretroviral therapy-naïve, restarting therapy after treatment discontinuation without prior virological failure or switching from existing stable treatment. Results: Sixty-seven patients were enrolled in the study and 41 patients completed treatment. In the primary analysis (intent-to-treat missing=failure) at week 48, 34% of patients (23/67; 95% CI: 23%-47%) had plasma HIV-1 RNA
AB - Objective: To assess efficacy, adherence and tolerability of once daily antiretroviral therapy containing tenofovir disoproxil fumarate (DF) 300 mg in HIV-1-infected former injecting drug users receiving opiate treatment (IVDU). Methods: European, 48-week, open-label, single-arm, multicenter study. Patients were either antiretroviral therapy-naïve, restarting therapy after treatment discontinuation without prior virological failure or switching from existing stable treatment. Results: Sixty-seven patients were enrolled in the study and 41 patients completed treatment. In the primary analysis (intent-to-treat missing=failure) at week 48, 34% of patients (23/67; 95% CI: 23%-47%) had plasma HIV-1 RNA
KW - HIV-1
KW - Injecting drug users
KW - Methadone
KW - Tenofovir DF
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M3 - Article
C2 - 22024421
AN - SCOPUS:80055030076
VL - 16
SP - 427
EP - 436
JO - European Journal of Medical Research
JF - European Journal of Medical Research
SN - 0949-2321
IS - 10
ER -