ZUR WIRKSAMKEIT UND WIRKUNGSDAUER EINES NITROGLYCERINPFLASTERS BEI BELASTUNGSBEDINGTER ANGINA PECTORIS

Translated title of the contribution: Efficacy and duration of effect of a glyceryl trinitrate plaster in effort-induced angina pectoris

G. Schiavoni, M. Mazzari, G. Lanza

Research output: Contribution to journalArticle

Abstract

The study is based on an examination of 12 patients with angina pectoris caused by exercise. The information was attained with the aid of a cycloergometer test, which was done before, as well as 6, 24, and 28 hours after the application of a single 20 cm2 pad containing 104 mg of GTN. The nitro-pad led to a noticeable increase in tolerance to exercise in all patients admitted to the experiment. The quantity of work performed increased by 41% after the 6th hour and by 39% after the 24th hour in comparison with values before application of the pad. The duration of pain-free exercise increased from an average of 360 seconds before application of the nitro-pad to 510 seconds after 6 hours and to 500 seconds after 24 hours. The degree of the ST tract shift, measured at the moment of interruption of an exercise test, amounted initially to 2,1 mm, after 6 hours 0,7 mm and after 24 hours 0,5 mm. In a comparison between all the parameters evaluated between the 6th and 24th hour after application no significant differences were found. It can be concluded that the nitro-pad under test possesses a high degree of efficacy in the prophylaxis of angina pectoris induced by exercise; it has a length of action between 24 and 26 hours which is considerably higher than that of every other form of administration of nitrate presently in use.

Translated title of the contributionEfficacy and duration of effect of a glyceryl trinitrate plaster in effort-induced angina pectoris
Original languageGerman
Pages (from-to)1401-1408
Number of pages8
JournalTherapiewoche
Volume35
Issue number12
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Pharmacology

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