Efficacy and Gastrointestinal Tolerability of Oral Oxycodone/Naloxone Combination for Chronic Pain in Outpatients With Cancer: An Observational Study

Arturo Cuomo; Gennaro Russo; Gennaro Esposito; Cira Antonietta Forte; Marianna Connola; Claudio Marcassa

doi:10.1177/1049909113510058

Efficacy and Gastrointestinal Tolerability of Oral Oxycodone/Naloxone Combination for Chronic Pain in Outpatients With Cancer: An Observational Study

Arturo Cuomo, Gennaro Russo, Gennaro Esposito, Cira Antonietta Forte, Marianna Connola, Claudio Marcassa

Research output: Contribution to journal › Article

Abstract

Combination opioid agonist/antagonist therapy has been shown to preserve bowel function in patients with chronic cancer pain. This retrospective study evaluated the efficacy and tolerability of prolonged-released fixed-dose oxycodone-naloxone (PR OXN) in consecutive outpatients with chronic cancer pain. Of 206 patients prescribed PR OXN (mean age 61.3 ± 12.9 years; 52.9% female), 31.5% were opioid naïve. PR OXN was associated with a significant decrease in pain score measured on a visual analogue scale over 28 days (P

Original language	English
Pages (from-to)	867-876
Number of pages	10
Journal	American Journal of Hospice and Palliative Medicine
Volume	31
Issue number	8
DOIs	https://doi.org/10.1177/1049909113510058
Publication status	Published - Dec 10 2014

Keywords

advanced cancer pain
chronic cancer pain
combination therapy
opioid-induced constipation
outpatients
oxycodone/naloxone

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1177/1049909113510058

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Cuomo, A., Russo, G., Esposito, G., Forte, C. A., Connola, M., & Marcassa, C. (2014). Efficacy and Gastrointestinal Tolerability of Oral Oxycodone/Naloxone Combination for Chronic Pain in Outpatients With Cancer: An Observational Study. American Journal of Hospice and Palliative Medicine, 31(8), 867-876. https://doi.org/10.1177/1049909113510058

Efficacy and Gastrointestinal Tolerability of Oral Oxycodone/Naloxone Combination for Chronic Pain in Outpatients With Cancer : An Observational Study. / Cuomo, Arturo ; Russo, Gennaro ; Esposito, Gennaro; Forte, Cira Antonietta; Connola, Marianna; Marcassa, Claudio.

In: American Journal of Hospice and Palliative Medicine, Vol. 31, No. 8, 10.12.2014, p. 867-876.

Research output: Contribution to journal › Article

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