TY - JOUR
T1 - Efficacy and Gastrointestinal Tolerability of Oral Oxycodone/Naloxone Combination for Chronic Pain in Outpatients With Cancer
T2 - An Observational Study
AU - Cuomo, Arturo
AU - Russo, Gennaro
AU - Esposito, Gennaro
AU - Forte, Cira Antonietta
AU - Connola, Marianna
AU - Marcassa, Claudio
PY - 2014/12/10
Y1 - 2014/12/10
N2 - Combination opioid agonist/antagonist therapy has been shown to preserve bowel function in patients with chronic cancer pain. This retrospective study evaluated the efficacy and tolerability of prolonged-released fixed-dose oxycodone-naloxone (PR OXN) in consecutive outpatients with chronic cancer pain. Of 206 patients prescribed PR OXN (mean age 61.3 ± 12.9 years; 52.9% female), 31.5% were opioid naïve. PR OXN was associated with a significant decrease in pain score measured on a visual analogue scale over 28 days (P
AB - Combination opioid agonist/antagonist therapy has been shown to preserve bowel function in patients with chronic cancer pain. This retrospective study evaluated the efficacy and tolerability of prolonged-released fixed-dose oxycodone-naloxone (PR OXN) in consecutive outpatients with chronic cancer pain. Of 206 patients prescribed PR OXN (mean age 61.3 ± 12.9 years; 52.9% female), 31.5% were opioid naïve. PR OXN was associated with a significant decrease in pain score measured on a visual analogue scale over 28 days (P
KW - advanced cancer pain
KW - chronic cancer pain
KW - combination therapy
KW - opioid-induced constipation
KW - outpatients
KW - oxycodone/naloxone
UR - http://www.scopus.com/inward/record.url?scp=84915817771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84915817771&partnerID=8YFLogxK
U2 - 10.1177/1049909113510058
DO - 10.1177/1049909113510058
M3 - Article
AN - SCOPUS:84915817771
VL - 31
SP - 867
EP - 876
JO - American Journal of Hospice and Palliative Medicine
JF - American Journal of Hospice and Palliative Medicine
SN - 1049-9091
IS - 8
ER -