Efficacy and maintenance strategies of two-compound formulation calcipotriol and betamethasone dipropionate gel (Xamiol® gel) in the treatment of scalp psoriasis: Results from a study in 885 patients

Rosita Saraceno, Germana Camplone, Magda D'Agostino, Clara De Simone, Antonella Di Cesare, Giorgio Filosa, Pasquale Frascione, Massimo Gabellini, Franco Lunghi, Annamaria Mazzotta, Ketty Peris, Genoveffa Scotto Di Luzio, Stefano Calvieri, Marco Simonacci, Sergio Chimenti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Previous studies showed the efficacy of a formulation containing calcipotriol and betamethasone dipropionate for the treatment of psoriasis. Objective: To investigate maintenance strategies of a formulation containing calcipotriol (50 g/g) and betamethasone dipropionate (0.5 mg/g) for the treatment of scalp psoriasis. Materials and methods: Nine-hundred and four patients were screened and randomised on a 1:1 basis in two groups: maintenance of two applications per week (group A) versus on-demand therapy (group B). Clinical evaluation was performed at weeks 0, 2, 4, 8 and 12. Results: Eight-hundred and eighty-five patients were randomised: 441 in group A and 444 in group B. From week 2, both groups showed a significant clinical improvement compared with baseline; at weeks 8 and 12, group A demonstrated a higher clinical response compared with group B (p <0.05). This difference was statistically significant (OR 0.47, 95% CI 0.37, 0.60). Conclusions: The maintenance of twice-weekly application versus on-demand treatment of calcipotriol/betamethasone dipropionate gel is more effective and is associated with a lower rate of relapse.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalJournal of Dermatological Treatment
Volume25
Issue number1
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Calcipotriol/betamethasone dipropionate
  • Gel formulation
  • IGA
  • PGA
  • Scalp psoriasis
  • SSA
  • TSS
  • Two-compound product

ASJC Scopus subject areas

  • Dermatology

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