Efficacy and safety evaluation of pentoxifylline associated with other antioxidants in medical treatment of Peyronie’s disease: A case-control study

Gianni Paulis, Davide Barletta, Paolo Turchi, Antonio Vitarelli, Giuseppe Dachille, Andrea Fabiani, Romano Gennaro

Research output: Contribution to journalArticlepeer-review

Abstract

Peyronie’s disease (PD) is a chronic disorder involving the tunica albuginea surrounding the corpora cavernosa of the penis. A conservative treatment is indicated in the first stage of disease. The aim of this study was to assess the therapeutic impact and possible side effects of treatment with pentoxifylline (PTX) in combination with other antioxidants in 307 patients with early-stage PD. Patients were subdivided into three groups: A, B, and C. Both groups, A and B, comprising of 206 patients, underwent treatment, whereas Group C was the control group (n=101). Treatment lasted 6 months and included the following: Group A: PTX 400 mg twice a day + propolis 600 mg/d + blueberry 160 mg/d + vitamin E 600 mg/d + diclofenac 4% gel twice/a day + PTX 100 mg via perilesional penile injection/every other week (12 injections in all); Group B: the same treatment as Group A except for the penile PTX injections. After the 6-month treatment course, we obtained the following results: actual mean decrease in plaque volume −46.9% and −24.8% in Group A and B, respectively (P

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalResearch and Reports in Urology
Volume8
DOIs
Publication statusPublished - Dec 31 2015

Keywords

  • Antioxidant supplementation
  • Multimodal treatment
  • Penile curvature
  • Penile injections

ASJC Scopus subject areas

  • Urology

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