Efficacy and safety of a topically applied avéne spring water spray in the healing of facial skin after laser resurfacing

L. Sulimovic, D. Licu, E. Ledo, J. M. Naeyaert, P. Pigatto, C. Tzermias, J. Vasquez Doval, P. Dupuy

Research output: Contribution to journalArticlepeer-review


BACKGROUND. Although laser resurfacing is a well-accepted treatment, tolerance problems may preclude patient's acceptance of the procedure. Post-laser protracted erythema is a prime problem, associated with the symptoms of pain, itching, stinging and tightening. OBJECTIVE. The present study was conducted to evaluate a low-salt medical spring water (Avéne, Avéne-les-Bains, France), in conjunction with the standard use of an emollient, to improve tolerance by hydrating the postlaser skin. METHODS. A controlled, randomized, open-labeled, multicentric and two parallel group study was completed after 84 days in 74 patients, 34 applying a petrolatum ointment alone (control group), and 40 applying petrolatum ointment in association with the Avéne spring water spray ad libitum (water group). RESULTS. The water spray showed a pronounced effect on reducing erythema, from the second week of postlaser onwards, with a statistically significant difference in favor of the water group compared with the control group (p ≤ 0.04 from day 14 to day 84, except a non-significant trend on day 28). In addition, the water spray was found to significantly reduce itching on day 28 (p <0.05), and stinging and tightening on day 14 and day 21 (p <0.05). Pain was not modified by the water. CONCLUSION. Topical water appears to be a helpful adjunctive treatment to petrolatum ointment for counteracting erythema, itching, stinging and tightening during the postlaser treatment period.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalDermatologic Surgery
Issue number5
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Dermatology
  • Surgery


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