Efficacy and safety of abaloparatide for the treatment of post-menopausal osteoporosis

D. Merlotti, A. Falchetti, I. Chiodini, L. Gennari

Research output: Contribution to journalArticlepeer-review


Introduction: Osteoporosis is a skeletal disorder characterized by loss of bone mass and strength affecting up to 30–50% of postmenopausal women worldwide. Current therapeutic options include antiresorptives such as aminobisphosphonates or denosumab and osteoanabolic compounds such as teriparatide. Areas covered: In this review, the authors summarize the clinical development, safety and efficacy profile of abaloparatide, a new osteoanabolic agent recently marketed in the US for the treatment of postmenopausal osteoporosis in women who are at high risk for fracture or who fail antiresorptive therapy. Expert opinion: Abaloparatide is a 1-34 PTH related peptide-like molecule that has been modified in order to potentiate the osteoanabolic effect. In its pivotal phase 3 trial in postmenopausal women with osteoporosis, subcutaneous abaloparatide 80 mcg/day reduced the risk of vertebral, nonvertebral, major osteoporotic, and clinical fractures compared with placebo and reduced the risk of major osteoporotic fractures compared with teriparatide. These results, together with a reduced prevalence of hypercalcemia and a lower cost of the marketed compound, point toward improved cost effectiveness with abaloparatide versus teriparatide. However, some concerns have been raised due to a somewhat higher occurrence of adverse effects (particularly with palpitations and increased heart rate) or the resultant discontinuation due to these adverse effects when compared to teriparatide.

Original languageEnglish
Pages (from-to)805-811
Number of pages7
JournalExpert Opinion on Pharmacotherapy
Issue number7
Publication statusPublished - May 3 2019


  • Abaloparatide
  • bone formation
  • osteoporosis treatment
  • postmenopausal osteoporosis
  • teriparatide

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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