Efficacy and safety of an amino-acid-based formula during the period of weaning children with intestinal failure and parenteral nutrition

Maria Immacolata Spagnuolo, Maria Anaela Caiazzo, Maria Rosaria Pirrozzi, Maria Pia Cicalese, Brunella Aceto, Renato Raul Valsasina, Stefano Piccolrovazzi

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Intestinal failure is the loss of intestinal function due to intestinal diseases, like short bowel syndrome and/or other primary intestinal defects, or to systemic conditions involving the bowel secondarily. Intestinal failure can be reversible or permanent. Patients with intestinal failure require parenteral nutrition for a variable period to survive. It is not well established which formula should be used for weaning from parenteral nutrition. The aim of this study was to assess the impact of a new amino-acid-based formula (Humana SINEALL) on nutritional status and its safety in children with in-testinal failure during 4 weeks of observation. Patients and Methods: We conducted a prospective study in a group of patients aged 2 months to 17 years, followed in our pediatrics department for intestinal failure with different etiologies from October 2007 to February 2008. Nutritional status and feeding tolerance were assessed during 4 weeks of nutritional rehabilitation from parenteral nutrition using the new amino-acid-based formula. For each child we recorded gender, age, body weight, height, body mass index, and serum levels of nutritional biochemical parameters including albumin, prealbumin, iron, ferritin, calcium, and insulin-like growth factor-1. We also tested blood xylose and urinary iodine. All parameters were recorded at the time of enrolment (TO) and after 4 weeks of dietary management (T1). Results: Twenty-two patients (11 males) with a mean age of 4.38 ± 4.63 years were enrolled. Mean z-scored body weight increased from -2.01 ± 0.31 to 0.5 ± 0.98 (p

Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalNutritional Therapy and Metabolism
Volume30
Issue number1
Publication statusPublished - Jan 2012

Keywords

  • Amino acid-based formula
  • Children
  • Intestinal failure
  • Parenteral nutrition
  • Weaning

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

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