TY - JOUR
T1 - Efficacy and safety of an amino-acid-based formula during the period of weaning children with intestinal failure and parenteral nutrition
AU - Spagnuolo, Maria Immacolata
AU - Caiazzo, Maria Anaela
AU - Pirrozzi, Maria Rosaria
AU - Cicalese, Maria Pia
AU - Aceto, Brunella
AU - Valsasina, Renato Raul
AU - Piccolrovazzi, Stefano
PY - 2012/1
Y1 - 2012/1
N2 - Introduction: Intestinal failure is the loss of intestinal function due to intestinal diseases, like short bowel syndrome and/or other primary intestinal defects, or to systemic conditions involving the bowel secondarily. Intestinal failure can be reversible or permanent. Patients with intestinal failure require parenteral nutrition for a variable period to survive. It is not well established which formula should be used for weaning from parenteral nutrition. The aim of this study was to assess the impact of a new amino-acid-based formula (Humana SINEALL) on nutritional status and its safety in children with in-testinal failure during 4 weeks of observation. Patients and Methods: We conducted a prospective study in a group of patients aged 2 months to 17 years, followed in our pediatrics department for intestinal failure with different etiologies from October 2007 to February 2008. Nutritional status and feeding tolerance were assessed during 4 weeks of nutritional rehabilitation from parenteral nutrition using the new amino-acid-based formula. For each child we recorded gender, age, body weight, height, body mass index, and serum levels of nutritional biochemical parameters including albumin, prealbumin, iron, ferritin, calcium, and insulin-like growth factor-1. We also tested blood xylose and urinary iodine. All parameters were recorded at the time of enrolment (TO) and after 4 weeks of dietary management (T1). Results: Twenty-two patients (11 males) with a mean age of 4.38 ± 4.63 years were enrolled. Mean z-scored body weight increased from -2.01 ± 0.31 to 0.5 ± 0.98 (p
AB - Introduction: Intestinal failure is the loss of intestinal function due to intestinal diseases, like short bowel syndrome and/or other primary intestinal defects, or to systemic conditions involving the bowel secondarily. Intestinal failure can be reversible or permanent. Patients with intestinal failure require parenteral nutrition for a variable period to survive. It is not well established which formula should be used for weaning from parenteral nutrition. The aim of this study was to assess the impact of a new amino-acid-based formula (Humana SINEALL) on nutritional status and its safety in children with in-testinal failure during 4 weeks of observation. Patients and Methods: We conducted a prospective study in a group of patients aged 2 months to 17 years, followed in our pediatrics department for intestinal failure with different etiologies from October 2007 to February 2008. Nutritional status and feeding tolerance were assessed during 4 weeks of nutritional rehabilitation from parenteral nutrition using the new amino-acid-based formula. For each child we recorded gender, age, body weight, height, body mass index, and serum levels of nutritional biochemical parameters including albumin, prealbumin, iron, ferritin, calcium, and insulin-like growth factor-1. We also tested blood xylose and urinary iodine. All parameters were recorded at the time of enrolment (TO) and after 4 weeks of dietary management (T1). Results: Twenty-two patients (11 males) with a mean age of 4.38 ± 4.63 years were enrolled. Mean z-scored body weight increased from -2.01 ± 0.31 to 0.5 ± 0.98 (p
KW - Amino acid-based formula
KW - Children
KW - Intestinal failure
KW - Parenteral nutrition
KW - Weaning
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M3 - Article
AN - SCOPUS:84867570164
VL - 30
SP - 42
EP - 50
JO - Rivista Italiana di Nutrizione Parenterale ed Enterale
JF - Rivista Italiana di Nutrizione Parenterale ed Enterale
SN - 1828-6232
IS - 1
ER -