Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection

C. Giannitti; M. Benucci; R. Caporali; S. Manganelli; F. Bellisai; G. D. Sebastiani; Mauro Galeazzi

Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection

C. Giannitti, M. Benucci, R. Caporali, S. Manganelli, F. Bellisai, G. D. Sebastiani, Mauro Galeazzi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

This study further expands our previous observation demonstrating the usefulness of combination therapy of anti-TNF-alpha and Cyclosporine A in the treatment of rheumatoid arthritis and concurrent hepatitis C virus infection, as well its efficacy and safety in controlling HCV viremia and liver toxicity. Seven patients were included in the study; transaminase levels remained unchanged, HCV RNA serum levels decreased significantly and DAS 28 significantly improved after twelve month follow-up. No side effects were registered.

Original language	English
Pages (from-to)	543-546
Number of pages	4
Journal	International Journal of Immunopathology and Pharmacology
Volume	22
Issue number	2
Publication status	Published - Apr 2009

Keywords

Anti TNF- α
CsA
HCV
Rheumatoid arthritis

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Pharmacology

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Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection. / Giannitti, C.; Benucci, M.; Caporali, R.; Manganelli, S.; Bellisai, F.; Sebastiani, G. D.; Galeazzi, Mauro.

In: International Journal of Immunopathology and Pharmacology, Vol. 22, No. 2, 04.2009, p. 543-546.

Research output: Contribution to journal › Article › peer-review

Giannitti, C. ; Benucci, M. ; Caporali, R. ; Manganelli, S. ; Bellisai, F. ; Sebastiani, G. D. ; Galeazzi, Mauro. / Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection. In: International Journal of Immunopathology and Pharmacology. 2009 ; Vol. 22, No. 2. pp. 543-546.

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