Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection

C. Giannitti; M. Benucci; R. Caporali; S. Manganelli; F. Bellisai; G. D. Sebastiani; Mauro Galeazzi

Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection

C. Giannitti, M. Benucci, R. Caporali, S. Manganelli, F. Bellisai, G. D. Sebastiani, Mauro Galeazzi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

This study further expands our previous observation demonstrating the usefulness of combination therapy of anti-TNF-alpha and Cyclosporine A in the treatment of rheumatoid arthritis and concurrent hepatitis C virus infection, as well its efficacy and safety in controlling HCV viremia and liver toxicity. Seven patients were included in the study; transaminase levels remained unchanged, HCV RNA serum levels decreased significantly and DAS 28 significantly improved after twelve month follow-up. No side effects were registered.

Original language	English
Pages (from-to)	543-546
Number of pages	4
Journal	International Journal of Immunopathology and Pharmacology
Volume	22
Issue number	2
Publication status	Published - Apr 2009

Keywords

Anti TNF- α
CsA
HCV
Rheumatoid arthritis

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Pharmacology

Cite this

Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection. / Giannitti, C.; Benucci, M.; Caporali, R. et al.

In: International Journal of Immunopathology and Pharmacology, Vol. 22, No. 2, 04.2009, p. 543-546.

Research output: Contribution to journal › Article › peer-review

@article{036918d4eb69411e856d62af039d9fd4,

title = "Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection",

abstract = "This study further expands our previous observation demonstrating the usefulness of combination therapy of anti-TNF-alpha and Cyclosporine A in the treatment of rheumatoid arthritis and concurrent hepatitis C virus infection, as well its efficacy and safety in controlling HCV viremia and liver toxicity. Seven patients were included in the study; transaminase levels remained unchanged, HCV RNA serum levels decreased significantly and DAS 28 significantly improved after twelve month follow-up. No side effects were registered.",

keywords = "Anti TNF- α, CsA, HCV, Rheumatoid arthritis",

author = "C. Giannitti and M. Benucci and R. Caporali and S. Manganelli and F. Bellisai and Sebastiani, {G. D.} and Mauro Galeazzi",

year = "2009",

month = apr,

language = "English",

volume = "22",

pages = "543--546",

journal = "International Journal of Immunopathology and Pharmacology",

issn = "0394-6320",

publisher = "Biomedical Research Press s.a.s.",

number = "2",

}

TY - JOUR

T1 - Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection

AU - Giannitti, C.

AU - Benucci, M.

AU - Caporali, R.

AU - Manganelli, S.

AU - Bellisai, F.

AU - Sebastiani, G. D.

AU - Galeazzi, Mauro

PY - 2009/4

Y1 - 2009/4

N2 - This study further expands our previous observation demonstrating the usefulness of combination therapy of anti-TNF-alpha and Cyclosporine A in the treatment of rheumatoid arthritis and concurrent hepatitis C virus infection, as well its efficacy and safety in controlling HCV viremia and liver toxicity. Seven patients were included in the study; transaminase levels remained unchanged, HCV RNA serum levels decreased significantly and DAS 28 significantly improved after twelve month follow-up. No side effects were registered.

AB - This study further expands our previous observation demonstrating the usefulness of combination therapy of anti-TNF-alpha and Cyclosporine A in the treatment of rheumatoid arthritis and concurrent hepatitis C virus infection, as well its efficacy and safety in controlling HCV viremia and liver toxicity. Seven patients were included in the study; transaminase levels remained unchanged, HCV RNA serum levels decreased significantly and DAS 28 significantly improved after twelve month follow-up. No side effects were registered.

KW - Anti TNF- α

KW - CsA

KW - HCV

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=67650477221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650477221&partnerID=8YFLogxK

M3 - Article

C2 - 19505408

AN - SCOPUS:67650477221

VL - 22

SP - 543

EP - 546

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

SN - 0394-6320

IS - 2

ER -

Efficacy and safety of anti-TNF-α therapy combined with cyclosporine a in patients with rheumatoid arthritis and concomitant hepatitis C virus infection

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this