Efficacy and safety of delapril plus manidipine compared with enalapril plus hydrochlorothiazide in mild to moderate essential hypertension: Results of a randomized trial

Amedeo Mugellini, Jurij Dobovisek, Danijel Planinc, Giovanni Cremonesi, Roberto Fogari

Research output: Contribution to journalArticle


The use of coombination therapy is required to achieve blood pressure targets in 40% to 75% of patients with hypertension. There have been few studies comparing the efficacy and tolerability of the new fixed combination of the angiotensin-converting enzyme (ACE) inhibitor delapril 30 mg and the calcium channel antagonist manidipine 10 mg with those of a standard combination of another ACE inhibitor and a diuretic. The aim of this study was to compare the antihypertensive efficacy and tolerability of delapril 30 mg given alone or with manidipine 10 mg with those of enalapril 20 mg given alone or with hydrochlorothiazide (HCTZ) 12.5 mg in patients with mild to moderate essential hypertension. This was a multicenter, active-controlled, parallel-group trial. After an initial 2-week placebo run-in period, patients aged 18 to 75 years with diastolic blood pressure (DBP)

Original languageEnglish
Pages (from-to)1419-1426
Number of pages8
JournalClinical Therapeutics
Issue number9
Publication statusPublished - Sep 2004



  • antihypertensive treatment
  • delapril
  • enalapril
  • essential hypertension
  • hydrochlorothiazide
  • manidipine

ASJC Scopus subject areas

  • Pharmacology

Cite this