Efficacy and safety of eribulin in taxane-refractory patients in the 'real world'

Vito Lorusso, Saverio Cinieri, Agnese Latorre, Luca Porcu, Lucia Del Mastro, Fabio Puglisi, Sandro Barni

Research output: Contribution to journalArticle

Abstract

Aim: Recent clinical, randomized and observational studies showed that eribulin, an analogous of Halichondrin B, was beneficial and well-tolerated in heavily pretreated metastatic breast cancer patients. Here, we aim to evaluate the effectiveness and safety of eribulin in taxane-refractory metastatic breast cancer patients. Patients & methods: In this subanalysis of the ESEMPIO study database, we selected 91 subjects with well-defined taxane refractoriness and complete data available. Results: 41 patients (45.2%) showed clinical benefit; one complete response (2.2%) and 16 partial responses (17.6%) were observed. Median progression-free survival and median overall survival were 3.1 and 11.6 months, respectively. The most experienced adverse event was asthenia/fatigue (58%), followed by neutropenia (30%). The treatment-related toxicity led to eribulin-dose reduction in 19 patients and suspension in nine. Conclusion: This study shows that eribulin is effective and well tolerated also in taxane-refractory patients in clinical practice.

Original languageEnglish
Pages (from-to)971-978
Number of pages8
JournalFuture Oncology
Volume13
Issue number11
DOIs
Publication statusPublished - May 1 2017

Keywords

  • eribulin
  • metastatic breast cancer
  • taxane-refractory

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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