The antiemetic activity of levosulpiride 25 mg IV was compared with that of metoclopramide 10 mg IV in 30 patients with bone metastasis secondary to pulmonary carcinoma who were treated with intravenous salmon calcitonin. In this randomized, double-blind, crossover study, levosulpiride was significantly more effective than metoclopramide in reducing the intensity of nausea and the number of vomiting episodes. No differences were seen when the drugs were administered in the first or second cycle of therapy, indicating that there was no carryover effect of one drug on the other. Levosulpiride was significantly better tolerated than metoclopramide. Not only did levosulpiride induce fewer side effects (11 versus 42 for metoclopramide), but it also reduced the number of undesired events caused by the elevated doses of salmon calcitonin (20 versus 48 for metoclopramide).
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