Efficacy and safety of netilmycin/dexamethasone preservative-free and tobramycin/dexamethasone-preserved fixed combination in patients after cataract surgery

Veronica Pianini, Andrea Passani, G. C M Rossi, Franco Passani

Research output: Contribution to journalArticle

Abstract

Purpose: To compare the efficacy and safety of preservative-free Netilmycin/Dexamethasone with that of preserved Tobramycin/Dexamethasone, postcataract surgery. Methods: Prospective, randomized, single-blind study on patients submitted to phacoemulsification. During preoperatory visits, at 7 and 21 days conjunctival hyperemia, corneal edema, Tyndall, Shirmer I, corneal and conjunctival lissamine green and fluorescein staining, and intraocular pressure (IOP) were recorded. Postoperative pain (at day 7) and the subjective tolerability (at day 21) were investigated. Results: Eighty patients completed the study and the data collected were analyzed (44 on Netilmycin/Dexamethasone). Regarding the primary efficacy variable, intraocular inflammation, no microbial events were recorded, but aqueous flare was significantly lower with Tobramycin/Dexamethasone at 1 week (P=0.002). Regarding secondary efficacy variables, conjunctival hyperemia was lower in patients under Tobramycin/Dexamethasone (P

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalJournal of Ocular Pharmacology and Therapeutics
Volume26
Issue number6
DOIs
Publication statusPublished - Dec 1 2010

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology (medical)
  • Pharmacology

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