Abstract
Background: The most frequent form of renal involvement in patients with hepatitis C infection is cryoglobulinemic membrano-proliferative glomerulonephritis. Nonetheless, some reports indicate that the eradication of the hepatitis C virus may also lead to the remission of this renal disease. Methods: The virological, immunological and nephrological response to pegylated interferon α plus ribavirin (48 weeks in patients infected with genotype 1, and 24 weeks for patients infected with genotypes 2 and 3) was evaluated retrospectively in 10 patients with cryoglobulinemic glomerulonephritis. Results: 6 patients obtained end of treatment virological response (60%); during follow-up, 2 relapsed, and 4 patients maintained a sustained virological response (40%). At the end of follow-up, three patients obtained a significant nephrological response and decrease in cryoglobulin levels (p<0.05). No significant changes in clinical and biological parameters were observed in non-responders/relapsers. Conclusions: Eradication of hepatitis C may be associated with the regression of cryoglobulinemic glomerulonephritis.
| Original language | English |
|---|---|
| Pages (from-to) | 613-616 |
| Number of pages | 4 |
| Journal | Digestive and Liver Disease |
| Volume | 47 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2015 |
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Keywords
- HCV-genotype
- Hepatitis C virus
- Membrano-proliferative glomerulo-nephritis
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Efficacy and safety of pegylated interferon plus ribavirin for the treatment of hepatitis C virus-positive cryoglobulinemic glomerulonephritis. / Mazzaro, Cesare; Panarello, Giacomo; Mauro, Endri; Gattei, Valter; Pozzato, Gabriele.
In: Digestive and Liver Disease, Vol. 47, No. 7, 01.07.2015, p. 613-616.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy and safety of pegylated interferon plus ribavirin for the treatment of hepatitis C virus-positive cryoglobulinemic glomerulonephritis
AU - Mazzaro, Cesare
AU - Panarello, Giacomo
AU - Mauro, Endri
AU - Gattei, Valter
AU - Pozzato, Gabriele
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background: The most frequent form of renal involvement in patients with hepatitis C infection is cryoglobulinemic membrano-proliferative glomerulonephritis. Nonetheless, some reports indicate that the eradication of the hepatitis C virus may also lead to the remission of this renal disease. Methods: The virological, immunological and nephrological response to pegylated interferon α plus ribavirin (48 weeks in patients infected with genotype 1, and 24 weeks for patients infected with genotypes 2 and 3) was evaluated retrospectively in 10 patients with cryoglobulinemic glomerulonephritis. Results: 6 patients obtained end of treatment virological response (60%); during follow-up, 2 relapsed, and 4 patients maintained a sustained virological response (40%). At the end of follow-up, three patients obtained a significant nephrological response and decrease in cryoglobulin levels (p<0.05). No significant changes in clinical and biological parameters were observed in non-responders/relapsers. Conclusions: Eradication of hepatitis C may be associated with the regression of cryoglobulinemic glomerulonephritis.
AB - Background: The most frequent form of renal involvement in patients with hepatitis C infection is cryoglobulinemic membrano-proliferative glomerulonephritis. Nonetheless, some reports indicate that the eradication of the hepatitis C virus may also lead to the remission of this renal disease. Methods: The virological, immunological and nephrological response to pegylated interferon α plus ribavirin (48 weeks in patients infected with genotype 1, and 24 weeks for patients infected with genotypes 2 and 3) was evaluated retrospectively in 10 patients with cryoglobulinemic glomerulonephritis. Results: 6 patients obtained end of treatment virological response (60%); during follow-up, 2 relapsed, and 4 patients maintained a sustained virological response (40%). At the end of follow-up, three patients obtained a significant nephrological response and decrease in cryoglobulin levels (p<0.05). No significant changes in clinical and biological parameters were observed in non-responders/relapsers. Conclusions: Eradication of hepatitis C may be associated with the regression of cryoglobulinemic glomerulonephritis.
KW - HCV-genotype
KW - Hepatitis C virus
KW - Membrano-proliferative glomerulo-nephritis
UR - http://www.scopus.com/inward/record.url?scp=84937640706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937640706&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2015.03.020
DO - 10.1016/j.dld.2015.03.020
M3 - Article
C2 - 25890508
AN - SCOPUS:84937640706
VL - 47
SP - 613
EP - 616
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 7
ER -