Efficacy and safety of the combination of docetaxel (Taxotere®) with targeted therapies in the treatment of solid malignancies

Vincenzo Emanuele Chiuri, Nicola Silvestris, Andrea Tinelli, Vito Lorusso

Research output: Contribution to journalArticle

Abstract

Docetaxel is a chemotherapeutic drug which has recently demonstrated high efficacy in the treatment of a wide variety of tumors. Numerous novel targeted drugs are being introduced in preclinical and clinical practice, aiming to directly inhibit pathways responsible for the maintenance of transformed and immortalized phenotypes of cancer cells. Herein we reported the efficacy and safety results of the most significant clinical trials evaluating different combinations and schedules of docetaxel plus biological therapeutics.

Original languageEnglish
Pages (from-to)982-1000
Number of pages19
JournalCurrent Drug Targets
Volume10
Issue number10
DOIs
Publication statusPublished - 2009

Keywords

  • BCL-2
  • Docetaxel
  • Efficacy
  • EGFR
  • PDGFR
  • RTKI
  • Safety
  • Solid tumors
  • Targeted therapy
  • VEGFR

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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