Efficacy and tolerability of 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in wrinkle reduction of photodamaged skin

Antonella Piccioni, Maria Concetta Fargnoli, Spyridon Schoinas, Mariano Suppa, Pasquale Frascione, Agnese Ginebri, Sergio Chimenti, Ketty Peris

Research output: Contribution to journalArticle

Abstract

Background: Photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) is effective for the treatment of photoaging. Objective: To evaluate the efficacy and safety of PDT using a novel 0.5% liposome-encapsulated 5-ALA spray and an intense pulsed light (IPL) system (Ellipse Flex PPT) in reduction of periorbital and nasolabial wrinkles. Patients and Methods: Thirty healthy volunteers, aged 3565 years, skin type IIII, with type 2 photoaging underwent a baseline visit, three ALA-IPL treatments once every 3 weeks, an end-of-treatment visit and a final visit 3 months after the end-of-treatment visit. Wrinkle depth was evaluated according to the modified Fitzpatrick wrinkle scale (MFWS). At the final visit, patients rated their degree of overall improvement. Results: For periorbital and nasolabial wrinkles, the differences of the average MFWS evaluation between baseline versus end-of-treatment visit, baseline versus final visit and end-of-treatment visit versus final visit were statistically significant (p <0.001). The average overall improvement was greater for periorbital than for nasolabial wrinkles (p <0.001). No side effects were observed during and after treatment. The degree of overall improvement was scored as excellent by 47% of the volunteers. Conclusions: ALA-IPL treatment using 0.5% liposome-encapsulated 5-ALA spray and Ellipse Flex PPT system is effective and safe for the treatment of type 2 photoaging reducing the PDT-associated side effects.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalJournal of Dermatological Treatment
Volume22
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • 5-aminolevulinic acid
  • intense pulsed light
  • photoaging
  • photodynamic therapy

ASJC Scopus subject areas

  • Dermatology

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