Efficacia e tollerabilità di una crema isolante e riparatrice in soggetti con dermatite da contatto delle mani

Translated title of the contribution: Efficacy and tolerability of a barrier cream in subjects with hand contact dermatitis

Antonio Cristaudo, Anna Conserva, Agnes Gougerot, Toni Marius A Ionesco, Anne Marie Matta, Marcello Pellicano, Enzo Berardesca

Research output: Contribution to journalArticle

Abstract

Contact dermatitis of the hands is a chronic and difficult to treat skin condition. A new generation of barrier creams based on polymers have been proven to be effective in the decrease of allergens and irritants that penetrate human skin. Poly-2p® is an association of pyrrolidone and phosphorylcholine polymers within a W/O emulsion, which acts as a barrier complex, insulating and repairing stratum corneum. The purpose of this study was to evaluate the efficacy, tolerability and cosmetic properties of this new isolating and restoring cream* under usual conditions of use and over a period of one month, in patients with contact dermatitis of the hands. Two visits were scheduled V1 (D0) and V2 (D30). Clinical features including a description of the lesions, product tolerability as well as the cream's cosmetic properties and subject compliance with treatment were recorded at both visits. 24 subjects, eight males and 16 females, aged between 18 and 58 (average 41.7) from a variety of occupations (waiters, mechanics, office workers) were included in the study. Personal history of atopy was present in 12.5% of the patients. 29.2% of the subjects had used cosmetic products during the previous 4-5 weeks and 66.7% were under medical treatment. Subjects usually washed their hands 20 to 40 times a day or more in 33% of cases. The cream was applied at least five times a day for 30 days. None of the patients experienced any adverse reactions. The results showed a statistically significant improvement (p1 to V2 relative to the extent and the severity of the lesions. The global severity decreased statistically in all patients. Symptoms intensity and frequency (burn, itching, redness, dryness, scaling) decreased significantly during the study. The safety was judged excellent in more than 95% of cases. The majority of patients were satisfied with the efficacy and the cosmetic qualities of the cream. All the patients expressed their intention to continue using the cream. In conclusion, this study has demonstrated that this cream, when applied regularly and continuously is effective, well tolerated and appreciated by the patients.

Original languageItalian
Pages (from-to)24-28
Number of pages5
JournalAnnali Italiani di Dermatologia Allergologica Clinica e Sperimentale
Volume62
Issue number1
Publication statusPublished - Jan 2008

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Contact Dermatitis
Hand
Cosmetics
Polymers
Pyrrolidinones
Skin
Phosphorylcholine
Irritants
Pruritus
Emulsions
Mechanics
Occupations
Allergens
Cornea
Safety
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy

Cite this

Efficacia e tollerabilità di una crema isolante e riparatrice in soggetti con dermatite da contatto delle mani. / Cristaudo, Antonio; Conserva, Anna; Gougerot, Agnes; Ionesco, Toni Marius A; Matta, Anne Marie; Pellicano, Marcello; Berardesca, Enzo.

In: Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale, Vol. 62, No. 1, 01.2008, p. 24-28.

Research output: Contribution to journalArticle

Cristaudo, Antonio ; Conserva, Anna ; Gougerot, Agnes ; Ionesco, Toni Marius A ; Matta, Anne Marie ; Pellicano, Marcello ; Berardesca, Enzo. / Efficacia e tollerabilità di una crema isolante e riparatrice in soggetti con dermatite da contatto delle mani. In: Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale. 2008 ; Vol. 62, No. 1. pp. 24-28.
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abstract = "Contact dermatitis of the hands is a chronic and difficult to treat skin condition. A new generation of barrier creams based on polymers have been proven to be effective in the decrease of allergens and irritants that penetrate human skin. Poly-2p{\circledR} is an association of pyrrolidone and phosphorylcholine polymers within a W/O emulsion, which acts as a barrier complex, insulating and repairing stratum corneum. The purpose of this study was to evaluate the efficacy, tolerability and cosmetic properties of this new isolating and restoring cream* under usual conditions of use and over a period of one month, in patients with contact dermatitis of the hands. Two visits were scheduled V1 (D0) and V2 (D30). Clinical features including a description of the lesions, product tolerability as well as the cream's cosmetic properties and subject compliance with treatment were recorded at both visits. 24 subjects, eight males and 16 females, aged between 18 and 58 (average 41.7) from a variety of occupations (waiters, mechanics, office workers) were included in the study. Personal history of atopy was present in 12.5{\%} of the patients. 29.2{\%} of the subjects had used cosmetic products during the previous 4-5 weeks and 66.7{\%} were under medical treatment. Subjects usually washed their hands 20 to 40 times a day or more in 33{\%} of cases. The cream was applied at least five times a day for 30 days. None of the patients experienced any adverse reactions. The results showed a statistically significant improvement (p1 to V2 relative to the extent and the severity of the lesions. The global severity decreased statistically in all patients. Symptoms intensity and frequency (burn, itching, redness, dryness, scaling) decreased significantly during the study. The safety was judged excellent in more than 95{\%} of cases. The majority of patients were satisfied with the efficacy and the cosmetic qualities of the cream. All the patients expressed their intention to continue using the cream. In conclusion, this study has demonstrated that this cream, when applied regularly and continuously is effective, well tolerated and appreciated by the patients.",
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