Abstract
Contact dermatitis of the hands is a chronic and difficult to treat skin condition. A new generation of barrier creams based on polymers have been proven to be effective in the decrease of allergens and irritants that penetrate human skin. Poly-2p® is an association of pyrrolidone and phosphorylcholine polymers within a W/O emulsion, which acts as a barrier complex, insulating and repairing stratum corneum. The purpose of this study was to evaluate the efficacy, tolerability and cosmetic properties of this new isolating and restoring cream* under usual conditions of use and over a period of one month, in patients with contact dermatitis of the hands. Two visits were scheduled V1 (D0) and V2 (D30). Clinical features including a description of the lesions, product tolerability as well as the cream's cosmetic properties and subject compliance with treatment were recorded at both visits. 24 subjects, eight males and 16 females, aged between 18 and 58 (average 41.7) from a variety of occupations (waiters, mechanics, office workers) were included in the study. Personal history of atopy was present in 12.5% of the patients. 29.2% of the subjects had used cosmetic products during the previous 4-5 weeks and 66.7% were under medical treatment. Subjects usually washed their hands 20 to 40 times a day or more in 33% of cases. The cream was applied at least five times a day for 30 days. None of the patients experienced any adverse reactions. The results showed a statistically significant improvement (p1 to V2 relative to the extent and the severity of the lesions. The global severity decreased statistically in all patients. Symptoms intensity and frequency (burn, itching, redness, dryness, scaling) decreased significantly during the study. The safety was judged excellent in more than 95% of cases. The majority of patients were satisfied with the efficacy and the cosmetic qualities of the cream. All the patients expressed their intention to continue using the cream. In conclusion, this study has demonstrated that this cream, when applied regularly and continuously is effective, well tolerated and appreciated by the patients.
| Original language | Italian |
|---|---|
| Pages (from-to) | 24-28 |
| Number of pages | 5 |
| Journal | Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale |
| Volume | 62 |
| Issue number | 1 |
| Publication status | Published - Jan 2008 |
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ASJC Scopus subject areas
- Dermatology
- Immunology and Allergy
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Efficacia e tollerabilità di una crema isolante e riparatrice in soggetti con dermatite da contatto delle mani. / Cristaudo, Antonio; Conserva, Anna; Gougerot, Agnes; Ionesco, Toni Marius A; Matta, Anne Marie; Pellicano, Marcello; Berardesca, Enzo.
In: Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale, Vol. 62, No. 1, 01.2008, p. 24-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacia e tollerabilità di una crema isolante e riparatrice in soggetti con dermatite da contatto delle mani
AU - Cristaudo, Antonio
AU - Conserva, Anna
AU - Gougerot, Agnes
AU - Ionesco, Toni Marius A
AU - Matta, Anne Marie
AU - Pellicano, Marcello
AU - Berardesca, Enzo
PY - 2008/1
Y1 - 2008/1
N2 - Contact dermatitis of the hands is a chronic and difficult to treat skin condition. A new generation of barrier creams based on polymers have been proven to be effective in the decrease of allergens and irritants that penetrate human skin. Poly-2p® is an association of pyrrolidone and phosphorylcholine polymers within a W/O emulsion, which acts as a barrier complex, insulating and repairing stratum corneum. The purpose of this study was to evaluate the efficacy, tolerability and cosmetic properties of this new isolating and restoring cream* under usual conditions of use and over a period of one month, in patients with contact dermatitis of the hands. Two visits were scheduled V1 (D0) and V2 (D30). Clinical features including a description of the lesions, product tolerability as well as the cream's cosmetic properties and subject compliance with treatment were recorded at both visits. 24 subjects, eight males and 16 females, aged between 18 and 58 (average 41.7) from a variety of occupations (waiters, mechanics, office workers) were included in the study. Personal history of atopy was present in 12.5% of the patients. 29.2% of the subjects had used cosmetic products during the previous 4-5 weeks and 66.7% were under medical treatment. Subjects usually washed their hands 20 to 40 times a day or more in 33% of cases. The cream was applied at least five times a day for 30 days. None of the patients experienced any adverse reactions. The results showed a statistically significant improvement (p1 to V2 relative to the extent and the severity of the lesions. The global severity decreased statistically in all patients. Symptoms intensity and frequency (burn, itching, redness, dryness, scaling) decreased significantly during the study. The safety was judged excellent in more than 95% of cases. The majority of patients were satisfied with the efficacy and the cosmetic qualities of the cream. All the patients expressed their intention to continue using the cream. In conclusion, this study has demonstrated that this cream, when applied regularly and continuously is effective, well tolerated and appreciated by the patients.
AB - Contact dermatitis of the hands is a chronic and difficult to treat skin condition. A new generation of barrier creams based on polymers have been proven to be effective in the decrease of allergens and irritants that penetrate human skin. Poly-2p® is an association of pyrrolidone and phosphorylcholine polymers within a W/O emulsion, which acts as a barrier complex, insulating and repairing stratum corneum. The purpose of this study was to evaluate the efficacy, tolerability and cosmetic properties of this new isolating and restoring cream* under usual conditions of use and over a period of one month, in patients with contact dermatitis of the hands. Two visits were scheduled V1 (D0) and V2 (D30). Clinical features including a description of the lesions, product tolerability as well as the cream's cosmetic properties and subject compliance with treatment were recorded at both visits. 24 subjects, eight males and 16 females, aged between 18 and 58 (average 41.7) from a variety of occupations (waiters, mechanics, office workers) were included in the study. Personal history of atopy was present in 12.5% of the patients. 29.2% of the subjects had used cosmetic products during the previous 4-5 weeks and 66.7% were under medical treatment. Subjects usually washed their hands 20 to 40 times a day or more in 33% of cases. The cream was applied at least five times a day for 30 days. None of the patients experienced any adverse reactions. The results showed a statistically significant improvement (p1 to V2 relative to the extent and the severity of the lesions. The global severity decreased statistically in all patients. Symptoms intensity and frequency (burn, itching, redness, dryness, scaling) decreased significantly during the study. The safety was judged excellent in more than 95% of cases. The majority of patients were satisfied with the efficacy and the cosmetic qualities of the cream. All the patients expressed their intention to continue using the cream. In conclusion, this study has demonstrated that this cream, when applied regularly and continuously is effective, well tolerated and appreciated by the patients.
KW - Barrier cream
KW - Contact dermatitis
KW - Phosphorylcholine
KW - Poly-2p®
KW - Polymers
KW - Pyrrolidone
KW - Skin protection
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UR - http://www.scopus.com/inward/citedby.url?scp=79952090343&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:79952090343
VL - 62
SP - 24
EP - 28
JO - Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale
JF - Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale
SN - 1592-6826
IS - 1
ER -