Efficacia e tollerabilità di un collutorio a base di diclofenac nel trattamento delle affezioni delle alte vie respiratorie

Studio in doppia cecità verso flurbiprofen collutorio

Translated title of the contribution: Efficacy and tolerability of a mouthwash based on diclofenac in the treatment of disorders of the upper respiratory tract. Double blind study versus flurbiprofen mouthwash

F. Pagella, V. Rossi, E. Zanoletti, M. Benazzo, E. Mira

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. Diclofenac, a non steroidal anti-inflammatory drug, performs its mechanism of action through an inhibition of prostaglandins synthesis. The authors have evaluated the therapeutic efficacy of the new diclofenac mouth wash. Methods. Sixty patients (36 M, 24 F) were enrolled in the study, with a mean age of 42.6 years ± 14.6 SD suffering from pharyngitis (46 cases), pharyngolaryngitis (8 cases) and pharyngotonsillitis (6 cases). The patients were subdivided into two homogeneous groups of 30 patients each. In the study, carried out according to a double blind experimental design, diclofenac mouthwash (0.074 %) and flurbiprofen mouthwash (0.25 %) were administered according to a dosage scheme involving 2 rinsings or gargarisms a day (15 mL) for a period of 7 days. Results. The results highlight the therapeutic efficacy and tolerability of both treatments. With the mouthwash based on diclofenac, there was however a more significant decrease in pain symptoms (pharyngodynia, odynophagia). Conclusions. Thus diclofenac mouthwash may be considered as a valid local treatment in oropharyngeal inflammations of mild/moderate severity.

Original languageItalian
Pages (from-to)77-81
Number of pages5
JournalOtorinolaringologia
Volume51
Issue number2
Publication statusPublished - 2001

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Mouthwashes
Flurbiprofen
Diclofenac
Double-Blind Method
Respiratory System
Therapeutics
Pharyngitis
Prostaglandins
Mouth
Anti-Inflammatory Agents
Research Design
Inflammation
Pain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{64d041d6e8364180902fa0de73027016,
title = "Efficacia e tollerabilit{\`a} di un collutorio a base di diclofenac nel trattamento delle affezioni delle alte vie respiratorie: Studio in doppia cecit{\`a} verso flurbiprofen collutorio",
abstract = "Background. Diclofenac, a non steroidal anti-inflammatory drug, performs its mechanism of action through an inhibition of prostaglandins synthesis. The authors have evaluated the therapeutic efficacy of the new diclofenac mouth wash. Methods. Sixty patients (36 M, 24 F) were enrolled in the study, with a mean age of 42.6 years ± 14.6 SD suffering from pharyngitis (46 cases), pharyngolaryngitis (8 cases) and pharyngotonsillitis (6 cases). The patients were subdivided into two homogeneous groups of 30 patients each. In the study, carried out according to a double blind experimental design, diclofenac mouthwash (0.074 {\%}) and flurbiprofen mouthwash (0.25 {\%}) were administered according to a dosage scheme involving 2 rinsings or gargarisms a day (15 mL) for a period of 7 days. Results. The results highlight the therapeutic efficacy and tolerability of both treatments. With the mouthwash based on diclofenac, there was however a more significant decrease in pain symptoms (pharyngodynia, odynophagia). Conclusions. Thus diclofenac mouthwash may be considered as a valid local treatment in oropharyngeal inflammations of mild/moderate severity.",
keywords = "Anti inflammatory agents, Diclofenac, Drug therapy, Flurbiprofen, Non steroidal, Pharyngitis",
author = "F. Pagella and V. Rossi and E. Zanoletti and M. Benazzo and E. Mira",
year = "2001",
language = "Italian",
volume = "51",
pages = "77--81",
journal = "Otorinolaringologia",
issn = "0026-4938",
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T1 - Efficacia e tollerabilità di un collutorio a base di diclofenac nel trattamento delle affezioni delle alte vie respiratorie

T2 - Studio in doppia cecità verso flurbiprofen collutorio

AU - Pagella, F.

AU - Rossi, V.

AU - Zanoletti, E.

AU - Benazzo, M.

AU - Mira, E.

PY - 2001

Y1 - 2001

N2 - Background. Diclofenac, a non steroidal anti-inflammatory drug, performs its mechanism of action through an inhibition of prostaglandins synthesis. The authors have evaluated the therapeutic efficacy of the new diclofenac mouth wash. Methods. Sixty patients (36 M, 24 F) were enrolled in the study, with a mean age of 42.6 years ± 14.6 SD suffering from pharyngitis (46 cases), pharyngolaryngitis (8 cases) and pharyngotonsillitis (6 cases). The patients were subdivided into two homogeneous groups of 30 patients each. In the study, carried out according to a double blind experimental design, diclofenac mouthwash (0.074 %) and flurbiprofen mouthwash (0.25 %) were administered according to a dosage scheme involving 2 rinsings or gargarisms a day (15 mL) for a period of 7 days. Results. The results highlight the therapeutic efficacy and tolerability of both treatments. With the mouthwash based on diclofenac, there was however a more significant decrease in pain symptoms (pharyngodynia, odynophagia). Conclusions. Thus diclofenac mouthwash may be considered as a valid local treatment in oropharyngeal inflammations of mild/moderate severity.

AB - Background. Diclofenac, a non steroidal anti-inflammatory drug, performs its mechanism of action through an inhibition of prostaglandins synthesis. The authors have evaluated the therapeutic efficacy of the new diclofenac mouth wash. Methods. Sixty patients (36 M, 24 F) were enrolled in the study, with a mean age of 42.6 years ± 14.6 SD suffering from pharyngitis (46 cases), pharyngolaryngitis (8 cases) and pharyngotonsillitis (6 cases). The patients were subdivided into two homogeneous groups of 30 patients each. In the study, carried out according to a double blind experimental design, diclofenac mouthwash (0.074 %) and flurbiprofen mouthwash (0.25 %) were administered according to a dosage scheme involving 2 rinsings or gargarisms a day (15 mL) for a period of 7 days. Results. The results highlight the therapeutic efficacy and tolerability of both treatments. With the mouthwash based on diclofenac, there was however a more significant decrease in pain symptoms (pharyngodynia, odynophagia). Conclusions. Thus diclofenac mouthwash may be considered as a valid local treatment in oropharyngeal inflammations of mild/moderate severity.

KW - Anti inflammatory agents

KW - Diclofenac

KW - Drug therapy

KW - Flurbiprofen

KW - Non steroidal

KW - Pharyngitis

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