Efficacia e tollerabilita di un topico contenente clorexidina gluconato 0,1% e allantoina 1% nella medicazione di soluzioni di continuo cutanee

Translated title of the contribution: Efficacy and tolerability of a topical product containing chlorhexidine gluconate 0.1% and allantoin 1% in the treatment of skin lesions and ulcers

L. Brambilla, V. Boneschi

Research output: Contribution to journalArticle

Abstract

Background and aim. The use of a wide spectrum antiseptic with good tolerability may encourage the healing of broken skin resulting from minor surgery and ulcers. The efficacy and tolerability of a topical product containing chlorhexidine, an antiseptic with a marked antibacterial capacity, and allantoin, offering hydrating and keratolytic properties which foster the development of granulation tissue. Methods. An open retrospective study was carried out in 30 patients, 16 males and 14 females aged between 12 and 82 years old, with skin lesions caused by minor outpatient surgery, like curettage and diathermocoagulation (23 patients), lower limb chronic venous insufficiency (5 patients) or the action of external agents (2 patients). Enrolment in the study was random. The product was applied twice a day and results were inspected weekly or twice weekly. The clinical aspects of lesions and the extent of re-epithelialisation were assessed. A total of 29 patients were evaluated. Results. All the lesions healed within a period of between 1 and 8 weeks, without signs of bacterial infection. Tolerance and patient compliance were good. Conclusions. The use of a topical compound containing chlorhexidine and allantoin proved effective in avoiding infection and encouraging the healing process in the skin lesions examined in this study.

Original languageItalian
Pages (from-to)391-394
Number of pages4
JournalGiornale Italiano di Dermatologia e Venereologia
Volume134
Issue number4
Publication statusPublished - 1999

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Allantoin
Skin Ulcer
Minor Surgical Procedures
Local Anti-Infective Agents
Chlorhexidine
Skin
Re-Epithelialization
Venous Insufficiency
Curettage
Granulation Tissue
Proxy
Therapeutics
Patient Compliance
Ambulatory Surgical Procedures
Bacterial Infections
Ulcer
Lower Extremity
Retrospective Studies
chlorhexidine gluconate
Infection

ASJC Scopus subject areas

  • Dermatology

Cite this

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abstract = "Background and aim. The use of a wide spectrum antiseptic with good tolerability may encourage the healing of broken skin resulting from minor surgery and ulcers. The efficacy and tolerability of a topical product containing chlorhexidine, an antiseptic with a marked antibacterial capacity, and allantoin, offering hydrating and keratolytic properties which foster the development of granulation tissue. Methods. An open retrospective study was carried out in 30 patients, 16 males and 14 females aged between 12 and 82 years old, with skin lesions caused by minor outpatient surgery, like curettage and diathermocoagulation (23 patients), lower limb chronic venous insufficiency (5 patients) or the action of external agents (2 patients). Enrolment in the study was random. The product was applied twice a day and results were inspected weekly or twice weekly. The clinical aspects of lesions and the extent of re-epithelialisation were assessed. A total of 29 patients were evaluated. Results. All the lesions healed within a period of between 1 and 8 weeks, without signs of bacterial infection. Tolerance and patient compliance were good. Conclusions. The use of a topical compound containing chlorhexidine and allantoin proved effective in avoiding infection and encouraging the healing process in the skin lesions examined in this study.",
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AU - Boneschi, V.

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KW - Allantoin, therapeutic use

KW - Chlorhexidine, therapeutic use

KW - Skin ulcer drug therapy

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