Efficacy and tolerability of amlodipine 5 mg monotherapy in mild to moderate essential hypertension

Ignazio Simonetti, Claudio Michelassi, Enri Gliozheni, Gianfranco Gensini

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Abstract

The antihypertensive efficacy and tolerability of amlodipine 5 mg was evaluated in a subgroup of 3449 patients enrolled in an open multicentre study involving a total of 9295 patients with mild to moderate essential hypertension. After an initial 2-week washout period, patients with an average diastolic blood pressure ≤ 95 mm Hg and ≤ 115 mm Hg commenced treatment with amlodipine 5 mg once daily for 24 weeks. A significant reduction in both systolic (from 168 ± 14 to 143 ± 11 mm Hg p <0.0001) and diastolic (from 101 ± 6 to 83 ± 5 mm Hg; p <0.0001) sitting blood pressure was noted during the study. Heart rate was not affected. Amlodipine was generally well tolerated; 4.9% of patients were withdrawn because of adverse events. Results showed comparable efficacy and tolerability in elderly (> 65 years of age) as well as young (≤ 65 years of age) patients.

Original languageEnglish
Pages (from-to)132-136
Number of pages5
JournalClinical Drug Investigation
Volume13
Issue numberSUPPL. 1
Publication statusPublished - 1997

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Amlodipine
Blood Pressure
Antihypertensive Agents
Multicenter Studies
Essential Hypertension
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Simonetti, I., Michelassi, C., Gliozheni, E., & Gensini, G. (1997). Efficacy and tolerability of amlodipine 5 mg monotherapy in mild to moderate essential hypertension. Clinical Drug Investigation, 13(SUPPL. 1), 132-136.

Efficacy and tolerability of amlodipine 5 mg monotherapy in mild to moderate essential hypertension. / Simonetti, Ignazio; Michelassi, Claudio; Gliozheni, Enri; Gensini, Gianfranco.

In: Clinical Drug Investigation, Vol. 13, No. SUPPL. 1, 1997, p. 132-136.

Research output: Contribution to journalArticle

Simonetti, I, Michelassi, C, Gliozheni, E & Gensini, G 1997, 'Efficacy and tolerability of amlodipine 5 mg monotherapy in mild to moderate essential hypertension', Clinical Drug Investigation, vol. 13, no. SUPPL. 1, pp. 132-136.
Simonetti, Ignazio ; Michelassi, Claudio ; Gliozheni, Enri ; Gensini, Gianfranco. / Efficacy and tolerability of amlodipine 5 mg monotherapy in mild to moderate essential hypertension. In: Clinical Drug Investigation. 1997 ; Vol. 13, No. SUPPL. 1. pp. 132-136.
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