Valutazione di efficacia e tollerabilita dell'apomorfina (Apofin® fiale) somministrata in infusione continua sottocutanea mediante microinfusore temporizzato in pazienti affetti da morbo di Parkinson grave, complicato da blocchi motori pluriquotidiani

Translated title of the contribution: Efficacy and tolerability of apomorphine (Apofin®) administered in continuous subcutaneous unfusion in Parkinsonian patients suffering from severe motor fluctuations

F. Stocchi, L. Vacca, M. F. De Pandis, M. Torti, G. Nordera, M. Cattoni, S. Ruggieri

Research output: Contribution to journalArticle

Abstract

In this study the efficacy and tolerability of apomorphine (Apofin®) given subcutaneously using a micropump has been evaluated. The drug has been administered to a group of 20 (8 male and 12 female) of Parkinsonian patients suffering from severe motor fluctuations and dyskinesias. The patients received the continuous subcutaneous infusion 12 hours a day (mean dosage 3.6±0.5 mg/h) for 12 consecutive months. Apomorphine infusion induced a significative reduction of the time spent 'off' by the patients and an increase of the 'on' time already after one month of treatment and an improvement of the UPDRS rating scale (ADL, motor score, dyskinesias score). The results remain constant for the following 11 months of the study. The time 'off' decreased by 63% and the 'on' time increased by 36%. Nineteen out of 20 patients give a good evaluation of the treatment. The safety is very satisfactory, subcutaneous nodules were observed in all the patients, whereas the blood tests were normal.

Original languageItalian
Pages (from-to)217-223
Number of pages7
JournalNuova Rivista di Neurologia
Volume9
Issue number6
Publication statusPublished - 1999

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Apomorphine
Dyskinesias
Subcutaneous Infusions
Hematologic Tests
Activities of Daily Living
Safety
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

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title = "Valutazione di efficacia e tollerabilita dell'apomorfina (Apofin{\circledR} fiale) somministrata in infusione continua sottocutanea mediante microinfusore temporizzato in pazienti affetti da morbo di Parkinson grave, complicato da blocchi motori pluriquotidiani",
abstract = "In this study the efficacy and tolerability of apomorphine (Apofin{\circledR}) given subcutaneously using a micropump has been evaluated. The drug has been administered to a group of 20 (8 male and 12 female) of Parkinsonian patients suffering from severe motor fluctuations and dyskinesias. The patients received the continuous subcutaneous infusion 12 hours a day (mean dosage 3.6±0.5 mg/h) for 12 consecutive months. Apomorphine infusion induced a significative reduction of the time spent 'off' by the patients and an increase of the 'on' time already after one month of treatment and an improvement of the UPDRS rating scale (ADL, motor score, dyskinesias score). The results remain constant for the following 11 months of the study. The time 'off' decreased by 63{\%} and the 'on' time increased by 36{\%}. Nineteen out of 20 patients give a good evaluation of the treatment. The safety is very satisfactory, subcutaneous nodules were observed in all the patients, whereas the blood tests were normal.",
keywords = "Apomorphine, Dyskinesias, Fluctuations, Parkinson",
author = "F. Stocchi and L. Vacca and {De Pandis}, {M. F.} and M. Torti and G. Nordera and M. Cattoni and S. Ruggieri",
year = "1999",
language = "Italian",
volume = "9",
pages = "217--223",
journal = "Rivista di Neurologia",
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TY - JOUR

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AU - Stocchi, F.

AU - Vacca, L.

AU - De Pandis, M. F.

AU - Torti, M.

AU - Nordera, G.

AU - Cattoni, M.

AU - Ruggieri, S.

PY - 1999

Y1 - 1999

N2 - In this study the efficacy and tolerability of apomorphine (Apofin®) given subcutaneously using a micropump has been evaluated. The drug has been administered to a group of 20 (8 male and 12 female) of Parkinsonian patients suffering from severe motor fluctuations and dyskinesias. The patients received the continuous subcutaneous infusion 12 hours a day (mean dosage 3.6±0.5 mg/h) for 12 consecutive months. Apomorphine infusion induced a significative reduction of the time spent 'off' by the patients and an increase of the 'on' time already after one month of treatment and an improvement of the UPDRS rating scale (ADL, motor score, dyskinesias score). The results remain constant for the following 11 months of the study. The time 'off' decreased by 63% and the 'on' time increased by 36%. Nineteen out of 20 patients give a good evaluation of the treatment. The safety is very satisfactory, subcutaneous nodules were observed in all the patients, whereas the blood tests were normal.

AB - In this study the efficacy and tolerability of apomorphine (Apofin®) given subcutaneously using a micropump has been evaluated. The drug has been administered to a group of 20 (8 male and 12 female) of Parkinsonian patients suffering from severe motor fluctuations and dyskinesias. The patients received the continuous subcutaneous infusion 12 hours a day (mean dosage 3.6±0.5 mg/h) for 12 consecutive months. Apomorphine infusion induced a significative reduction of the time spent 'off' by the patients and an increase of the 'on' time already after one month of treatment and an improvement of the UPDRS rating scale (ADL, motor score, dyskinesias score). The results remain constant for the following 11 months of the study. The time 'off' decreased by 63% and the 'on' time increased by 36%. Nineteen out of 20 patients give a good evaluation of the treatment. The safety is very satisfactory, subcutaneous nodules were observed in all the patients, whereas the blood tests were normal.

KW - Apomorphine

KW - Dyskinesias

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KW - Parkinson

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M3 - Articolo

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