Efficacy and tolerability of doxazosin alone or in combination with chlorthalidone in essential hypertension

Chiara Troffa, Paolo Manunta, Paolo Dessì-Fulgheri, Antonio Pazzola, Giuseppe Sabino, Giovanna Patteri, Giancarlo Tonolo, Giuseppe Pupita, Nicola Glorioso, Mario Gitti, Alessandro Rappelli

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated (1) the efficacy and safety of doxazosin versus enalapril when added to a diuretic regimen in essential hypertensive patients and (2) the effect of doxazosin alone or combined with chlorthalidone on postural hemodynamics, the renin-angiotensin-aldosterone system, renal function, and plasma catecholamines. Doxazosin reduced blood pressure comparably to enalapril; when added to chlorthalidone, doxazosin showed an additive effect, although to a lesser extent than that obtained when enalapril was added to chlorthalidone. One patient treated with doxazosin alone stopped therapy because of severe headache. The hemodynamic and humoral response to tilting was comparable for doxazosin and enalapril either alone or in combination with chlorthalidone. In particular, no patient experienced symptomatic orthostatic hypotension after the first dosing of doxazosin even when the diuretic regimen was initiated. These findings confirm the efficacy and safety of doxazosin alone or in combination with diuretics.

Original languageEnglish
Pages (from-to)22-31
Number of pages10
JournalCurrent Therapeutic Research
Volume55
Issue number1
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Medicine(all)

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