Efficacy and tolerability of long-acting octreotide in the treatment of thymic tumors results of a pilot trial

Flavia Longo, Lucilla De Filippis, Andrea Zivi, Domenico Vitolo, Ester Del Signore, Bruno Gori, Daniele Diso, Marco Anile, Federico Venuta, Tiziano De Giacomo, Camillo Furio Coloni

Research output: Contribution to journalArticle

Abstract

Objectives: Octreotide is a somatostatin analog, long-acting formulations of which have been used experimentally for the treatment of patients with invasive tumors and/or residual disease after conventional therapies. The objective of this retrospective study was to evaluate the efficacy of longacting octreotide (Sandostatin LAR) for the treatment of thymic tumors, with a primary efficacy end point of progression-free survival. Methods: Between 1994 and 2010, 44 patients with thymic malignancies were evaluated. Twenty-seven patients underwent an OctreoScan, and 12 OctreoScan-positive patients were treated with long-acting octreotide at a dose of 20 mg, given as an intramuscular injection, every 2 weeks. Results: Treatment with long-acting octreotide gave the following results: 3 cases of partial response (25%), 5 cases of stable disease (42%), and 4 cases of progressive disease (33%), with an average progression-free survival of 8 months (range, 3 to 21). Treatment compliance and tolerability were good for all evaluated patients. Conclusions: The results of this study confirm the somatostatin receptor as a valid target for the treatment of thymic malignancies. Overall, therapy with long-acting somatostatin analogs seems to be safe and effective.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume35
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Octreotide
  • Somatostatin analogs
  • Thymic tumors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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