Efficacy and tolerability of sumatriptan in the treatment of multiple migraine attacks

G. Bussone, G. C. Manzoni, P. Cortelli, M. Roncolato, L. Fabbri, C. Benassuti

Research output: Contribution to journalArticle


This cross-over, double blind, randomized, multi-centre study evaluated the consistency of efficacy and safety of oral sumatriptan in 233 migraneurs. The patients received 50 mg oral sumatriptan or placebo for the treatment of 12 migraine attacks. Within each group of 4 attacks, three were treated with sumatriptan and one with placebo, according to a randomization list. Over all the attacks, the efficacy rate was statistically significant for sumatriptan against placebo at 2 or 4 hours (2 hours: sumatriptan 60%, PLO 38%, p

Original languageEnglish
Pages (from-to)272-278
Number of pages7
JournalNeurological Sciences
Issue number5
Publication statusPublished - Oct 2000



  • Efficacy
  • Migraine
  • Safety
  • Sumatriptan

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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