Efficacia e tollerabilità della zonisamide in add-on nel trattamento dell'epilessia secondaria a neoplasia cerebrale

Translated title of the contribution: Efficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy

M. Maschio, L. Dinapoli, B. Jandolo, F. Saveriano

Research output: Contribution to journalArticlepeer-review


Zonisamide (ZNS) is a broad spectrum antiepileptic drug (AED) showing efficacy in controlling seizures as add-on in adult and paediatric epilepsy. To date, no studies are available on ZNS in patients with braintumor-related epilepsy (BTRE). Aim of the study was to evaluate efficacy and tolerability of ZNS as add-on treatment in BTRE. We followed 6 patients suffering from BTRE treated with other AEDs and not experiencing adequate seizure control. Three patients underwent chemotherapy while being treated with ZNS. Mean duration of follow up was 8 months. Mean seizure number in the month prior to the introduction of ZNS had been 27.7/month. ZNS mean dose was of 283.3 mg/day. At last follow-up, the mean seizure number was reduced to 8.8/month. Two patients discontinued the drug because of side effects. There were no other reported side effects. Preliminary data on the use of ZNS in add-on in patients with BTRE indicate that this drug may represent a valid alternative as add-on in this particular patient population. However larger samples and more prolonged follow-up are necessary to draw definitive conclusions.

Translated title of the contributionEfficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy
Original languageItalian
Pages (from-to)195-197
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number140
Publication statusPublished - Apr 2010

ASJC Scopus subject areas

  • Clinical Neurology


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