Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection: An ordinary clinics retrospective investigation

Giustino Parruti, Ennio Polilli, Giuseppe Vittorio De Socio, Federica Sozio, Patrizia Marconi, Viviana Soddu, Margherita Dalessandro, Benedetto Maurizio Celesia, Giovanni Pellicanò, Giordano Madeddu, Jacopo Vecchiet, Francesco Di Masi, Elena Mazzotta, Tamara Ursini, Canio Martinelli, Paola Vitiello, Paolo Bonfanti, Luciano Nigro, Maria Stella Mura, Andrea AntinoriElena Ricci, Lamberto Manzoli

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART regimens in unselected patients treated in ordinary clinical settings. Methods: Retrospective analysis of data of all patients starting first-line HAART regimens in 1998 and 2006 at adhering centers in the Italian CISAI group. Results: For the 543 patients included, mean age was 39.1 ± 9.8y in 1998 and 41.0 ± 10.7y in 2006 (p=0.03), with a similar proportion of males. Baseline mean log10 HIV-RNA was 4.56 ± 0.97 copies/mL in 1998 vs 4.91 ± 0.96 copies/mL in 2006 (p

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalJournal of Antivirals and Antiretrovirals
Volume4
Issue number2
DOIs
Publication statusPublished - 2012

Keywords

  • AIDS
  • HAART
  • HAART efficacy
  • HAART toxicity
  • HIV
  • Late hiv presentation

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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