Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection: An ordinary clinics retrospective investigation

Giustino Parruti; Ennio Polilli; Giuseppe Vittorio De Socio; Federica Sozio; Patrizia Marconi; Viviana Soddu; Margherita Dalessandro; Benedetto Maurizio Celesia; Giovanni Pellicanò; Giordano Madeddu; Jacopo Vecchiet; Francesco Di Masi; Elena Mazzotta; Tamara Ursini; Canio Martinelli; Paola Vitiello; Paolo Bonfanti; Luciano Nigro; Maria Stella Mura; Andrea Antinori; Elena Ricci; Lamberto Manzoli

doi:10.4172/jaa.1000043

Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection: An ordinary clinics retrospective investigation

Giustino Parruti, Ennio Polilli, Giuseppe Vittorio De Socio, Federica Sozio, Patrizia Marconi, Viviana Soddu, Margherita Dalessandro, Benedetto Maurizio Celesia, Giovanni Pellicanò, Giordano Madeddu, Jacopo Vecchiet, Francesco Di Masi, Elena Mazzotta, Tamara Ursini, Canio Martinelli, Paola Vitiello, Paolo Bonfanti, Luciano Nigro, Maria Stella Mura, Andrea AntinoriElena Ricci, Lamberto Manzoli

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART regimens in unselected patients treated in ordinary clinical settings. Methods: Retrospective analysis of data of all patients starting first-line HAART regimens in 1998 and 2006 at adhering centers in the Italian CISAI group. Results: For the 543 patients included, mean age was 39.1 ± 9.8y in 1998 and 41.0 ± 10.7y in 2006 (p=0.03), with a similar proportion of males. Baseline mean log10 HIV-RNA was 4.56 ± 0.97 copies/mL in 1998 vs 4.91 ± 0.96 copies/mL in 2006 (p

Original language	English
Pages (from-to)	32-37
Number of pages	6
Journal	Journal of Antivirals and Antiretrovirals
Volume	4
Issue number	2
DOIs	https://doi.org/10.4172/jaa.1000043
Publication status	Published - 2012

Keywords

AIDS
HAART
HAART efficacy
HAART toxicity
HIV
Late hiv presentation

ASJC Scopus subject areas

Infectious Diseases
Virology

Access to Document

10.4172/jaa.1000043

Fingerprint Dive into the research topics of 'Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection: An ordinary clinics retrospective investigation'. Together they form a unique fingerprint.

Cite this

Parruti, G., Polilli, E., De Socio, G. V., Sozio, F., Marconi, P., Soddu, V., Dalessandro, M., Celesia, B. M., Pellicanò, G., Madeddu, G., Vecchiet, J., Di Masi, F., Mazzotta, E., Ursini, T., Martinelli, C., Vitiello, P., Bonfanti, P., Nigro, L., Mura, M. S., ... Manzoli, L. (2012). Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection: An ordinary clinics retrospective investigation. Journal of Antivirals and Antiretrovirals, 4(2), 32-37. https://doi.org/10.4172/jaa.1000043

Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection : An ordinary clinics retrospective investigation. / Parruti, Giustino; Polilli, Ennio; De Socio, Giuseppe Vittorio; Sozio, Federica; Marconi, Patrizia; Soddu, Viviana; Dalessandro, Margherita; Celesia, Benedetto Maurizio; Pellicanò, Giovanni; Madeddu, Giordano; Vecchiet, Jacopo; Di Masi, Francesco; Mazzotta, Elena; Ursini, Tamara; Martinelli, Canio; Vitiello, Paola; Bonfanti, Paolo; Nigro, Luciano; Mura, Maria Stella; Antinori, Andrea; Ricci, Elena; Manzoli, Lamberto.

In: Journal of Antivirals and Antiretrovirals, Vol. 4, No. 2, 2012, p. 32-37.

Research output: Contribution to journal › Article › peer-review

Parruti, G, Polilli, E, De Socio, GV, Sozio, F, Marconi, P, Soddu, V, Dalessandro, M, Celesia, BM, Pellicanò, G, Madeddu, G, Vecchiet, J, Di Masi, F, Mazzotta, E, Ursini, T, Martinelli, C, Vitiello, P, Bonfanti, P, Nigro, L, Mura, MS, Antinori, A, Ricci, E & Manzoli, L 2012, 'Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection: An ordinary clinics retrospective investigation', Journal of Antivirals and Antiretrovirals, vol. 4, no. 2, pp. 32-37. https://doi.org/10.4172/jaa.1000043

Parruti, Giustino ; Polilli, Ennio ; De Socio, Giuseppe Vittorio ; Sozio, Federica ; Marconi, Patrizia ; Soddu, Viviana ; Dalessandro, Margherita ; Celesia, Benedetto Maurizio ; Pellicanò, Giovanni ; Madeddu, Giordano ; Vecchiet, Jacopo ; Di Masi, Francesco ; Mazzotta, Elena ; Ursini, Tamara ; Martinelli, Canio ; Vitiello, Paola ; Bonfanti, Paolo ; Nigro, Luciano ; Mura, Maria Stella ; Antinori, Andrea ; Ricci, Elena ; Manzoli, Lamberto. / Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection : An ordinary clinics retrospective investigation. In: Journal of Antivirals and Antiretrovirals. 2012 ; Vol. 4, No. 2. pp. 32-37.

@article{3324a8dec1e74d6798cc864eca6c97dc,

title = "Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection: An ordinary clinics retrospective investigation",

abstract = "Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART regimens in unselected patients treated in ordinary clinical settings. Methods: Retrospective analysis of data of all patients starting first-line HAART regimens in 1998 and 2006 at adhering centers in the Italian CISAI group. Results: For the 543 patients included, mean age was 39.1 ± 9.8y in 1998 and 41.0 ± 10.7y in 2006 (p=0.03), with a similar proportion of males. Baseline mean log10 HIV-RNA was 4.56 ± 0.97 copies/mL in 1998 vs 4.91 ± 0.96 copies/mL in 2006 (p",

keywords = "AIDS, HAART, HAART efficacy, HAART toxicity, HIV, Late hiv presentation",

author = "Giustino Parruti and Ennio Polilli and {De Socio}, {Giuseppe Vittorio} and Federica Sozio and Patrizia Marconi and Viviana Soddu and Margherita Dalessandro and Celesia, {Benedetto Maurizio} and Giovanni Pellican{\`o} and Giordano Madeddu and Jacopo Vecchiet and {Di Masi}, Francesco and Elena Mazzotta and Tamara Ursini and Canio Martinelli and Paola Vitiello and Paolo Bonfanti and Luciano Nigro and Mura, {Maria Stella} and Andrea Antinori and Elena Ricci and Lamberto Manzoli",

year = "2012",

doi = "10.4172/jaa.1000043",

language = "English",

volume = "4",

pages = "32--37",

journal = "Journal of Antivirals and Antiretrovirals",

issn = "1948-5964",

publisher = "Omics Publishing Group",

number = "2",

}

TY - JOUR

T1 - Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection

T2 - An ordinary clinics retrospective investigation

AU - Parruti, Giustino

AU - Polilli, Ennio

AU - De Socio, Giuseppe Vittorio

AU - Sozio, Federica

AU - Marconi, Patrizia

AU - Soddu, Viviana

AU - Dalessandro, Margherita

AU - Celesia, Benedetto Maurizio

AU - Pellicanò, Giovanni

AU - Madeddu, Giordano

AU - Vecchiet, Jacopo

AU - Di Masi, Francesco

AU - Mazzotta, Elena

AU - Ursini, Tamara

AU - Martinelli, Canio

AU - Vitiello, Paola

AU - Bonfanti, Paolo

AU - Nigro, Luciano

AU - Mura, Maria Stella

AU - Antinori, Andrea

AU - Ricci, Elena

AU - Manzoli, Lamberto

PY - 2012

Y1 - 2012

N2 - Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART regimens in unselected patients treated in ordinary clinical settings. Methods: Retrospective analysis of data of all patients starting first-line HAART regimens in 1998 and 2006 at adhering centers in the Italian CISAI group. Results: For the 543 patients included, mean age was 39.1 ± 9.8y in 1998 and 41.0 ± 10.7y in 2006 (p=0.03), with a similar proportion of males. Baseline mean log10 HIV-RNA was 4.56 ± 0.97 copies/mL in 1998 vs 4.91 ± 0.96 copies/mL in 2006 (p

AB - Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART regimens in unselected patients treated in ordinary clinical settings. Methods: Retrospective analysis of data of all patients starting first-line HAART regimens in 1998 and 2006 at adhering centers in the Italian CISAI group. Results: For the 543 patients included, mean age was 39.1 ± 9.8y in 1998 and 41.0 ± 10.7y in 2006 (p=0.03), with a similar proportion of males. Baseline mean log10 HIV-RNA was 4.56 ± 0.97 copies/mL in 1998 vs 4.91 ± 0.96 copies/mL in 2006 (p

KW - AIDS

KW - HAART

KW - HAART efficacy

KW - HAART toxicity

KW - HIV

KW - Late hiv presentation

UR - http://www.scopus.com/inward/record.url?scp=84863557274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863557274&partnerID=8YFLogxK

U2 - 10.4172/jaa.1000043

DO - 10.4172/jaa.1000043

M3 - Article

AN - SCOPUS:84863557274

VL - 4

SP - 32

EP - 37

JO - Journal of Antivirals and Antiretrovirals

JF - Journal of Antivirals and Antiretrovirals

SN - 1948-5964

IS - 2

ER -

Efficacy of 1998 Vs 2006 first-line antiretroviral regimens for HIV infection: An ordinary clinics retrospective investigation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this