Efficacy of a new antihypertensive agent (indenolol) assessed by ambulatory blood pressure monitoring

B. Trimarco, G. Groothold, D. Bonaduce, A. Cuocolo, B. Ricciardelli, V. Canonico, R. Breglio, M. Condorelli

Research output: Contribution to journalArticlepeer-review


The effects of two-week treatment periods with indenolol (I) and metoprolol (M) were examined by 24-hour mean blood pressure (BP) monitoring in control conditions and during exercise stress test in 7 patients with essential hypertension, using the Oxford method. Both drugs induced a significant reduction in mean BP and heart rate (HR) as compared to pretreatment values (mean BP: from 1173 mmHg to 1064 after I, p <0.05 and to 1023 after M, p <0.01; HR: from 782 bpm to 662 after I, p <0.01 and to 672 after M, p <0.01). I and M induced a significant reduction in systolic and diastolic BP throughout the day and most of the night. During bicycle ergometer the basal and peak values of systolic and diastolic BP were significantly lower after both treatments as compared to the pretreatment values (both p <0.01). Our data suggest that I once a day possesses a substantial and consistent antihypertensive action, effective over most of the 24 hours.

Original languageEnglish
Pages (from-to)395-399
Number of pages5
JournalClinical and Experimental Hypertension
Issue number2-3
Publication statusPublished - 1985


  • Antihypertensive therapy
  • Blood pressure variability
  • Exercise stress test
  • Metoprolol

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology


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