Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: The Menfis randomized trial

L. M. Chiechi, G. Secreto, M. D'Amore, M. Fanelli, E. Venturelli, F. Cantatore, T. Valerio, G. Laselva, P. Loizzi

Research output: Contribution to journalArticle

Abstract

Objectives: To compare the effect of a soy rich diet and hormone replacement therapy (HRT) on the main biomarkers of bone turnover and bone mineral density (BMD) at postmenopausal age. Methods: 187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into a soy rich diet group, a HRT group, and a control group. Bone biomarkers and BMD were evaluated at baseline and after 6 months at the end of the study. Results: Diet is not as effective as HRT in reducing the postmenopausal turnover; however diet stimulates bone osteoblastic activity, as evidenced by significant increase in osteocalcin concentrations. BMD decreases significantly only in the control group, but not in the intervention groups. Conclusions: Our data suggest that soy products could be effective in reducing the risk of osteoporosis in asymptomatic postmenopausal women, but our findings should be confirmed before recommending the diet as a valid alternative to HRT.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalMaturitas
Volume42
Issue number4
DOIs
Publication statusPublished - Aug 30 2002

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Keywords

  • Isoflavones
  • Menopause
  • Osteoporosis
  • Prevention
  • Soy

ASJC Scopus subject areas

  • Ageing
  • Obstetrics and Gynaecology

Cite this

Chiechi, L. M., Secreto, G., D'Amore, M., Fanelli, M., Venturelli, E., Cantatore, F., Valerio, T., Laselva, G., & Loizzi, P. (2002). Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: The Menfis randomized trial. Maturitas, 42(4), 295-300. https://doi.org/10.1016/S0378-5122(02)00158-5