Efficacy of acetyl-cholinesterase-inhibitor (ACHEI) treatment in Alzheimer's disease: A 21-month follow-up "real world" study

Marco Calabria, Cristina Geroldi, Giulia Lussignoli, Federica Sabbatini, Orazio Zanetti

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Long-term efficacy of acetyl-cholinesterase-inhibitor (ACHEI) treatment in mild-to-moderate Alzheimer's disease (AD) is of great relevance for clinical routine and has been investigated over a 21-month period of treatment in a "real word" population. We investigated cognitive (mini mental state examination = MMSE) and functional (instrumental activities of daily living = IADL; activities of daily living = ADL) outcomes in 427 AD patients throughout the above period. At the end of the study, first-time drug takers (naives) declined by 1.2 MMSE points, whereas non-naives by 3.8 points. Predictors of responsiveness for first-time drug takers were MMSE score at baseline and MMSE points gained at 3 months of treatment. Further investigations are needed to shed light on the characteristics of responsiveness to a tailored ACHEI treatment for dementia.

Original languageEnglish
JournalArchives of Gerontology and Geriatrics
Volume49
Issue number1
DOIs
Publication statusPublished - Jul 2009

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Cholinesterase Inhibitors
Activities of Daily Living
dementia
Alzheimer Disease
drug
Therapeutics
Pharmaceutical Preparations
Dementia
examination
Population

Keywords

  • Acetyl-cholinesterase-inhibitor (ACHEI)
  • Alzheimer disease (AD)
  • Efficacy of ACHEI treatment
  • Observational study

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)

Cite this

Efficacy of acetyl-cholinesterase-inhibitor (ACHEI) treatment in Alzheimer's disease : A 21-month follow-up "real world" study. / Calabria, Marco; Geroldi, Cristina; Lussignoli, Giulia; Sabbatini, Federica; Zanetti, Orazio.

In: Archives of Gerontology and Geriatrics, Vol. 49, No. 1, 07.2009.

Research output: Contribution to journalArticle

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