Background: Primary or idiophatic hyperhidrosis (PH) is a chronic disorder of excessive eccrine sweating that mainly affects the axillae, the palms, the soles of the feet, and the face. The treatment options for PH involve a range of topical or systemic medications and/or surgical invasive techniques. Common topical treatments are aluminium salts that act by blocking the duct of the eccrine gland. Recently, a new low-residues thermophobic foam formulation containing 20% aluminium salts (sesquichlorhydrate) has been developped (R&D Mipharm, Milan, Italy). The foam formulation is easy to apply expecially in hairy body sites. Study Aim: The aim of this study was to evaluate the effectiveness of this new aluminum salts thermophobic foam in the treatment of axillary and palmar PH. Patients and Methods: In a single center, open-label, follow-up study, 19 patients affected by PH were enrolled. Minor test score and Dermatology Life Quality Index (DLQI) were utilized to evaluate amount and the impact on quality of life. The foam was applied to the dry and clean skin, every night during the first week and three times during the second week. The evaluation of the results was performed by patients' subjective reports (DLQI) collected at baseline, at 7 and 15 days after treatment; and by the objective comparison of Minor test at baseline, at 7 and 15 days after treatment. Patients were monitored throughout the study for adverse events. Results: All of the 19 enrolled patients completed the study. The foam induced a significant reduction of the Minor score in comparison with baseline values in both axillary (p=0.0002) and palm region (p=0.0047), The foam shows a positive impact in DLQI mainly in patients with axillary hyperhidrosis. No side effects were reported during the entire study duration by patients. Conclusion: This new foam has shown to be an effective topical treatment in reducing sweating in patients with primary axillary and palm hyperhidrosis. This formulation is well tolerated in the short term. Further studies are warranted to evaluate efficacy and safety in the medium and long term.
|Translated title of the contribution||Efficacy of an aluminum salts thermofobic foam in the treatment of axillary and palmar primary hyperidrosis|
|Number of pages||5|
|Publication status||Published - Jul 2005|
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