Efficacy of antiadhesive, antibiotic and antiseptic coatings in preventing catheter-related infections: Review

Gianfranco Donelli, I. Francolini

Research output: Contribution to journalArticle


In recent years, central venous catheters (CVCs) are increasingly used in clinical practice. However, complications such as local or systemic infections are frequent for both temporary and indwelling vascular catheters. Annually, in the United States of America there are more than 200,000 cases of nosocomial bloodstream infections (BSIs), of which 90% are related to the use of an intravascular device. These infections are associated with increased morbidity and mortality, prolonged hospitalization and growing medical costs. Technological treatments of polymer surfaces including coating the catheter with antimicrobial substances may be promising tools for prevention of catheter-associated infections. A large number of surface-treated central venous catheters are now commercially available. In this paper the features and the clinical efficacy of different antimicrobial coatings are reviewed.

Original languageEnglish
Pages (from-to)595-606
Number of pages12
JournalJournal of Chemotherapy
Issue number6
Publication statusPublished - 2001



  • Anti-adhesive coatings
  • Antibiotics
  • Antiseptics
  • Catheter-related infections
  • Central venous catheters

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

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