Efficacy of chelation therapy to remove aluminium intoxication

Alessandro Fulgenzi, Rachele De Giuseppe, Fabrizia Bamonti, Daniele Vietti, Maria Elena Ferrero

Research output: Contribution to journalArticle

Abstract

There is a distinct correlation between aluminium (Al) intoxication and neurodegenerative diseases (ND). We demonstrated how patients affected by ND showing Al intoxication benefit from short-term treatment with calcium disodium ethylene diamine tetraacetic acid (EDTA) (chelation therapy). Such therapy further improvedthrough daily treatment with the antioxidant Cellfood. In the present study we examined the efficacy of longterm treatment, using both EDTA and Cellfood. Slow intravenous treatment with the chelating agent EDTA (2 g/10 mL diluted in 500 mL physiological saline administered in 2 h) (chelation test) removed Al, which was detected (using inductively coupled plasma mass spectrometry) in urine samples collected from patients over 12 h. Patients that revealed Al intoxication (expressed in μg per g creatinine) underwent EDTA chelation therapy once aweek for tenweeks, then once every twoweeks for a further six or twelvemonths. At the end of treatment (a total of 22 or 34 chelation therapies, respectively), associatedwith daily assumption of Cellfood, Al levels in the urine samples were analysed. In addition, the following blood parameters were determined: homocysteine, vitamin B12, and folate, aswell as the oxidative status e.g. reactive oxygen species (ROS), total antioxidant capacity (TAC), oxidized LDL (oxLDL), and glutathione. Our re sults showed that Al intoxication reduced significantly following EDTA and Cellfood treatment, and clinical symptoms improved. After treatment, ROS, oxLDL, and homocysteine decreased significantly,whereas vitamin B12, folate and TAC improved significantly. In conclusion, our data show the efficacy of chelation therapy associated with Cellfood in subjects affected by Al intoxication who have developed ND.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalJournal of Inorganic Biochemistry
Volume152
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Aluminium
  • Chelation therapy
  • Intoxication

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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    Fulgenzi, A., De Giuseppe, R., Bamonti, F., Vietti, D., & Ferrero, M. E. (2015). Efficacy of chelation therapy to remove aluminium intoxication. Journal of Inorganic Biochemistry, 152, 214-218. https://doi.org/10.1016/j.jinorgbio.2015.09.007