Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial

Peter S. Sândor, L. Di Clemente, G. Coppola, U. Saenger, A. Fumal, D. Magis, L. Seidel, R. M. Agosti, J. Schoenen

Research output: Contribution to journalArticle

Abstract

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.

Original languageEnglish
Pages (from-to)713-715
Number of pages3
JournalNeurology
Volume64
Issue number4
Publication statusPublished - Feb 22 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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