Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial

Peter S. Sândor, L. Di Clemente, G. Coppola, U. Saenger, A. Fumal, D. Magis, L. Seidel, R. M. Agosti, J. Schoenen

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.

Original languageEnglish
Pages (from-to)713-715
Number of pages3
JournalNeurology
Volume64
Issue number4
Publication statusPublished - Feb 22 2005

Fingerprint

coenzyme Q10
Migraine Disorders
Randomized Controlled Trials
Placebos
Numbers Needed To Treat
Riboflavin
Nausea
Energy Metabolism
Headache

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sândor, P. S., Di Clemente, L., Coppola, G., Saenger, U., Fumal, A., Magis, D., ... Schoenen, J. (2005). Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology, 64(4), 713-715.

Efficacy of coenzyme Q10 in migraine prophylaxis : A randomized controlled trial. / Sândor, Peter S.; Di Clemente, L.; Coppola, G.; Saenger, U.; Fumal, A.; Magis, D.; Seidel, L.; Agosti, R. M.; Schoenen, J.

In: Neurology, Vol. 64, No. 4, 22.02.2005, p. 713-715.

Research output: Contribution to journalArticle

Sândor, PS, Di Clemente, L, Coppola, G, Saenger, U, Fumal, A, Magis, D, Seidel, L, Agosti, RM & Schoenen, J 2005, 'Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial', Neurology, vol. 64, no. 4, pp. 713-715.
Sândor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology. 2005 Feb 22;64(4):713-715.
Sândor, Peter S. ; Di Clemente, L. ; Coppola, G. ; Saenger, U. ; Fumal, A. ; Magis, D. ; Seidel, L. ; Agosti, R. M. ; Schoenen, J. / Efficacy of coenzyme Q10 in migraine prophylaxis : A randomized controlled trial. In: Neurology. 2005 ; Vol. 64, No. 4. pp. 713-715.
@article{5a20ac2ed0994424b9089c0dbf94c10a,
title = "Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial",
abstract = "Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50{\%}-responder-rate for attack frequency was 14.4{\%} for placebo and 47.6{\%} for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.",
author = "S{\^a}ndor, {Peter S.} and {Di Clemente}, L. and G. Coppola and U. Saenger and A. Fumal and D. Magis and L. Seidel and Agosti, {R. M.} and J. Schoenen",
year = "2005",
month = "2",
day = "22",
language = "English",
volume = "64",
pages = "713--715",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Efficacy of coenzyme Q10 in migraine prophylaxis

T2 - A randomized controlled trial

AU - Sândor, Peter S.

AU - Di Clemente, L.

AU - Coppola, G.

AU - Saenger, U.

AU - Fumal, A.

AU - Magis, D.

AU - Seidel, L.

AU - Agosti, R. M.

AU - Schoenen, J.

PY - 2005/2/22

Y1 - 2005/2/22

N2 - Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.

AB - Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.

UR - http://www.scopus.com/inward/record.url?scp=13844316604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844316604&partnerID=8YFLogxK

M3 - Article

C2 - 15728298

AN - SCOPUS:13844316604

VL - 64

SP - 713

EP - 715

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -