Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection

A systematic review and meta-analysis

Gianluca Ianiro, Marcello Maida, Johan Burisch, Claudia Simonelli, Georgina Hold, Marco Ventimiglia, Antonio Gasbarrini, Giovanni Cammarota

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Protocols for treating recurrent Clostridium difficile infection (rCDI) through faecal microbiota transplantation (FMT) are still not standardised. Our aim was to evaluate the efficacy of different FMT protocols for rCDI according to routes, number of infusions and infused material. Methods: MEDLINE, Embase, SCOPUS, Web of Science and the Cochrane Library were searched through 31 May 2017. Studies offering multiple infusions if a single infusion failed to cure rCDI were included. Data were combined through a random effects meta-analysis. Results: Fifteen studies (1150 subjects) were analysed. Multiple infusions increased efficacy rates overall (76% versus 93%) and in each route of delivery (duodenal delivery: 73% with single infusion versus 81% with multiple infusions; capsule: 80% versus 92%; colonoscopy: 78% versus 98% and enema: 56% versus 92%). Duodenal delivery and colonoscopy were associated, respectively, with lower efficacy rates (p = 0.039) and higher efficacy rates (p = 0.006) overall. Faecal amount ≤ 50 g (p = 0.006) and enema (p = 0.019) were associated with lower efficacy rates after a single infusion. The use of fresh or frozen faeces did not influence outcomes. Conclusions: Routes, number of infusions and faecal dosage may influence efficacy rates of FMT for rCDI. These findings could help to optimise FMT protocols in clinical practice.

Original languageEnglish
Pages (from-to)1232-1244
Number of pages13
JournalUnited European Gastroenterology Journal
Volume6
Issue number8
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Clostridium Infections
Clostridium difficile
Meta-Analysis
Enema
Colonoscopy
Library Science
Clinical Protocols
Feces
MEDLINE
Capsules
Fecal Microbiota Transplantation

Keywords

  • Clostridium difficile
  • faecal microbiota transplantation
  • faecal transplant
  • meta-analysis
  • systematic review

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection : A systematic review and meta-analysis. / Ianiro, Gianluca; Maida, Marcello; Burisch, Johan; Simonelli, Claudia; Hold, Georgina; Ventimiglia, Marco; Gasbarrini, Antonio; Cammarota, Giovanni.

In: United European Gastroenterology Journal, Vol. 6, No. 8, 01.10.2018, p. 1232-1244.

Research output: Contribution to journalArticle

Ianiro, Gianluca ; Maida, Marcello ; Burisch, Johan ; Simonelli, Claudia ; Hold, Georgina ; Ventimiglia, Marco ; Gasbarrini, Antonio ; Cammarota, Giovanni. / Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection : A systematic review and meta-analysis. In: United European Gastroenterology Journal. 2018 ; Vol. 6, No. 8. pp. 1232-1244.
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