Efficacy of extended release quetiapine fumarate monotherapy in elderly patients with major depressive disorder: Secondary analyses in subgroups of patients according to baseline anxiety, sleep disturbance, and pain levels

Stuart A. Montgomery, A. Carlo Altamura, Heikki Katila, Catherine Datto, Johan Szamosi, Hans Eriksson

Research output: Contribution to journalArticle

Abstract

This study evaluated extended release quetiapine fumarate (quetiapine XR) monotherapy in elderly patients with major depressive disorder (MDD) according to baseline levels of anxiety, sleep disturbance, and pain. Post-hoc analyses of data from an 11-week (9-week randomized-treatment, 2-week post-treatment phase), double-blind, placebo-controlled study of quetiapine XR (50-300 mg/day) monotherapy in elderly (≥66 years) patients (n=338) with MDD were carried out. Outcomes included randomization to week 9 change in Montgomery Åsberg Depression Rating Scale (MADRS) score and week 9 response (≥50% MADRS score reduction) rates. Post-hoc analyses were carried out to assess subgroups of patients with MDD according to baseline levels in terms of the following: higher or lower anxiety (Hamilton Rating Scale for Anxiety total score≥20 or <20, respectively); high or low sleep disturbance [Hamilton Rating Scale for Depression sleep disturbance factor (items 4+5+6) score≥5 or

Original languageEnglish
Pages (from-to)93-105
Number of pages13
JournalInternational Clinical Psychopharmacology
Volume29
Issue number2
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Anxiety
  • Elderly
  • Extended Release Quetiapine Fumarate
  • Major Depressive Disorder
  • Pain
  • Sleep Disturbance

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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