Efficacy of fingolimod and interferon beta-1b on cognitive, MRI, and clinical outcomes in relapsing–remitting multiple sclerosis: an 18-month, open-label, rater-blinded, randomised, multicentre study (the GOLDEN study)

G. Comi, F. Patti, M.A. Rocca, F.C. Mattioli, M.P. Amato, P. Gallo, D. Centonze, C. Pozzilli, F. Saccà, F.T. Bergh, M. Bartezaghi, R. Turrini, M. Filippi, For the Golden Study Group, F. Patti, C.G. Chisari, G.A. Marfia, D. Centonze, V.B. Morra, R. CapraC. Pozzilli, V. Bianchi, A. Ghezzi, M. Roscio, G. Comi, F. Sangalli, E. Pietrolongo, A. Francia, M.C. Danni, U. Nocentini, P. Bramanti, G. Tedeschi, D. Maimone, L.M.E. Grimaldi, E.A. Scarpini, A. Uccelli, M.P. Amato, M. Rottoli, S. Ruggieri, M. Trojano, R. Bergamaschi, F.T. Bergh, M. Buttmann, P. Rieckmann, A. Safavi

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)2436-2449
Number of pages14
JournalJournal of Neurology
Volume264
Issue number12
DOIs
Publication statusPublished - 2017

Keywords

  • azathioprine
  • beta1a interferon
  • fingolimod
  • gadolinium
  • glatiramer
  • interferon beta serine
  • mitoxantrone
  • natalizumab, adult
  • Article
  • brain size
  • clinical feature
  • clinical outcome
  • cognition
  • connective tissue disease
  • contrast enhancement
  • controlled study
  • Delis-Kaplan executive function system
  • disease course
  • disease severity
  • drug efficacy
  • drug safety
  • drug tolerability
  • executive function test
  • Expanded Disability Status Scale
  • eye disease
  • female
  • gastrointestinal disease
  • hematologic disease
  • human
  • infection
  • infestation
  • injection site reaction
  • injury
  • intoxication
  • kidney disease
  • lymphatic system disease
  • major clinical study
  • male
  • mediastinum disease
  • mental disease
  • metabolic disorder
  • Montgomery Asberg Depression Rating Scale
  • multicenter study
  • multiple sclerosis
  • musculoskeletal disease
  • neuroimaging
  • neurologic disease
  • nuclear magnetic resonance imaging
  • nutritional disorder
  • open study
  • paced auditory serial addition test
  • pilot study
  • priority journal
  • randomized controlled trial
  • Rao Brief Repeatable Battery
  • recurrence risk
  • respiratory tract disease
  • risk assessment
  • risk benefit analysis
  • side effect
  • skin disease
  • symbol digit modalities test
  • thorax disease
  • treatment duration
  • urinary tract disease
  • vascular disease

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