Efficacy of FOLFOXIRI plus bevacizumab in liver-limited metastatic colorectal cancer: A pooled analysis of clinical studies by Gruppo Oncologico del Nord Ovest.

Chiara Cremolini, Mariaelena Casagrande, Fotios Loupakis, Giuseppe Aprile, Francesca Bergamo, Gianluca Masi, Roberto Moretto R, Filippo Pietrantonio, Federica Marmorino, Gemma Zucchelli, Gianluca Tomasello, Giuseppe Tonini, Giacomo Allegrini, Cristina Granetto, Laura Ferrari, Lucio Urbani, Umberto Cillo, Pierluigi Pilati, Elisa Sensi, Alessio PellegrinelliMassimo Milione, Gabriella Fontanini, Alfredo Falcone

Research output: Contribution to journalArticle

Abstract

Secondary resection is a chance of cure for a subgroup of metastatic colorectal cancer (mCRC) patients with unresectable liver-limited disease. Medical treatment has a dual goal: to induce tumour shrinkage and to prevent disease relapse. The aims of the present analysis were to assess the efficacy of FOLFOXIRI plus bevacizumab in this setting, and to investigate whether this regimen could revert the poor prognosis of high-risk patients defined by clinical and molecular factors. We performed a pooled analysis of patients with unresectable and liver-limited mCRC, treated with first-line FOLFOXIRI plus bevacizumab in three prospective clinical trials by Gruppo Oncologico del Nord Ovest. 205 (37.9 patients with liver-limited disease were selected, out of 541 treated patients. Liver metastases were synchronous, textgreater/=4 and bilobar in 90 61 and 79% of cases, respectively. The largest diameter was textgreater5 cm in 42% of cases, and textgreater/=6 segments were involved in 25 Seventy-four patients (36.1 underwent R0 or R1 resection of metastases. R2 resections were performed in 17 cases (8.3. Having textless6 involved segments (p textless 0.001) and achieving RECIST response (p = 0.019) were associated with higher chances of resection. R0/R1 resected patients had significantly longer median progression-free survival (PFS) (18.1 versus 10.7 months, HR: 0.48 [0.35-0.66], p textless 0.001) and overall survival (OS) (44.3 versus 24.4 months, HR: 0.32 [0.22-0.48], p textless 0.001) compared with other patients, both in the univariate and multivariate analyses (PFS p = 0.025; OS p textless 0.001). The
Original languageUndefined/Unknown
Pages (from-to)74-84
Number of pages11
JournalEuropean Journal of Cancer
Volume73
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • Bevacizumab, FOLFOXIRI, Liver metastases, Metastatic colorectal cancer

Cite this

Cremolini, C., Casagrande, M., Loupakis, F., Aprile, G., Bergamo, F., Masi, G., Moretto R, R., Pietrantonio, F., Marmorino, F., Zucchelli, G., Tomasello, G., Tonini, G., Allegrini, G., Granetto, C., Ferrari, L., Urbani, L., Cillo, U., Pilati, P., Sensi, E., ... Falcone, A. (2017). Efficacy of FOLFOXIRI plus bevacizumab in liver-limited metastatic colorectal cancer: A pooled analysis of clinical studies by Gruppo Oncologico del Nord Ovest. European Journal of Cancer, 73, 74-84. https://doi.org/10.1016/j.ejca.2016.10.028