Efficacy of insulin analogs in achieving the hemoglobin A 1c target of

Dario Giugliano, Maria Ida Maiorino, Giuseppe Bellastella, Paolo Chiodini, Antonio Ceriello, Katherine Esposito

Research output: Contribution to journalArticlepeer-review


OBJECTIVE - Insulin analogs are increasingly used in patients with type 2 diabetes. We compared the effect of basal, biphasic, prandial, and basal-bolus insulin regimens with insulin analogs to reach the hemoglobin A 1c (HbA 1c) target of 1c target of 30. RESULTS - We found 16 RCTs,with 20 comparisons and 7,759 patients. A greater proportion of patients achieved the HbA1c goal of ,7% with both biphasic (odds ratio 1.88 [95% CI 1.38-2.55]) and prandial (2.07 [1.16-3.69]) insulin compared with basal insulin; this was associated for biphasic insulin with greater hypoglycemia (event/patient/30 days, mean difference, 0.34 [range 0-0.69]) and weight gain in kg (1.0 kg [0.28-1.73]). Compared with biphasic insulin, the basal-bolus regimen was associated with a greater chance to reach the HbA 1c goal (odds ratio 1.75 [95% CI 1.11-2.77]), with no greater hypoglycemia or weight gain. The effect of insulin analogs on long-term diabetes complications is still lacking. CONCLUSIONS - A greater proportion of type 2 diabetic patients can achieve the HbA 1c goal 1c goal.

Original languageEnglish
Pages (from-to)510-517
Number of pages8
JournalDiabetes Care
Issue number2
Publication statusPublished - Feb 2011

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing


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