Efficacy of intranasal administration of neostigmine in myasthenic patients

Angelo Sghirlanzoni, Davide Pareyson, Claudio Benvenuti, Giovanni Cei, Vittorio Cosi, Mariella Lombardi, Mariaflavia Nicora, Roberta Ricciardi, Ferdinando Cornelio

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of intranasally administered neostigmine was tested in 22 patients with generalized myasthenia gravis (MG). Topical therapy to the highly vascularized oropharynx proved to be quickly effective in 5-15 min both clinically and electrophysiologically. Twenty-eight MG patients were then recruited from different centres and their morning doses of oral pyridostigmine were substituted with intranasal neostigmine over a period of 2 or 3 weeks. Intranasal neostigmine proved to be equally efficacious in this regimen. No side-effect was noted even in 4 patients treated in this way for 1 year. Intranasal administration of anti-acetylcholinesterase may be very beneficial: (1) for patients with irregular absorption of oral doses; (2) early in the morning and every time a fast and temporary effect is needed; (3) in bulbar impairment and emergencies, in which a handy atomizer may be life-saving.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalJournal of Neurology
Volume239
Issue number3
DOIs
Publication statusPublished - Mar 1992

Keywords

  • Autoimmunity
  • Cholinesterase inhibitors
  • Intranasal administration
  • Myasthenia gravis
  • Neostigmine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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