Efficacy of intranasal virosomal influenza vaccine in the prevention of recurrent acute otitis media in children

Paola Marchisio, Roberta Cavagna, Barbara Maspes, Stefania Gironi, Susanna Esposito, Lara Lambertini, Alessandra Massimini, Christian Herzog, Nicola Principi

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the efficacy of an intranasal, inactivated, virosomal subunit influenza vaccine for prevention of new episodes of acute otitis media (AOM) in children with recurrent AOM, 133 children aged 1-5 years were randomized to receive the vaccine (n = 67) or no vaccination (n = 66). During a 6-month period, 24 (35.8%) vaccine recipients had 32 episodes of AOM; 42 (63.6%) control subjects had 64 episodes. The overall efficacy of vaccination in preventing AOM was 43.7% (95% confidence interval, 18.6-61.1; P = .002). Children vaccinated before influenza season had a significantly better outcome than did those vaccinated after the onset of influenza season. The cumulative duration of middle ear effusion was significantly less in vaccinated children than in control subjects. Data suggest that the intranasal virosomal influenza vaccine might be considered among the options for the prevention of AOM in children

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalClinical Infectious Diseases
Volume35
Issue number2
DOIs
Publication statusPublished - Jul 15 2002

ASJC Scopus subject areas

  • Immunology

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