Efficacy of intraventricular amikacin treatment in pan-resistant pseudomonas aeruginosa postsurgical meningitis

Mariadelfina Molinaro, Paola Morelli, Manuela De Gregori, Simona De Gregori, Ilaria Giardini, Federica Tordato, Vincenzina Monzillo, Daria Pocaterra, Erminia Casari

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We describe a case of pan-resistant Pseudomonas aeruginosa postsurgical meningitis associated with the presence of an external ventricular device. We changed therapy twice; finally, by using amikacin and a continuous infusion of cefepime, we obtained clinical improvement. Case presentation: A female patient, who underwent surgery for a cavernous angioma, presented with meningitis. Cerebrospinal fluid culture revealed a multidrug-resistant Pseudomonas aeruginosa, initially sensitive only to colistin. We successfully used intrathecal amikacin and intravenous cefepime continuous infusion plus intravenous amikacin after two previous ineffective therapeutic approaches. Conclusion: The evaluation of the antibiotic concentration and the bactericidal activity in cerebrospinal fluid may contribute to the choice of the drug in cases of multidrug-resistant meningitis.

Original languageEnglish
Pages (from-to)1369-1372
Number of pages4
JournalInfection and Drug Resistance
Volume11
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Amikacin
  • Pan-resistant meningitis
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

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