Efficacy of intraventricular amikacin treatment in pan-resistant pseudomonas aeruginosa postsurgical meningitis

Research output: Contribution to journalArticle

Abstract

Background: We describe a case of pan-resistant Pseudomonas aeruginosa postsurgical meningitis associated with the presence of an external ventricular device. We changed therapy twice; finally, by using amikacin and a continuous infusion of cefepime, we obtained clinical improvement. Case presentation: A female patient, who underwent surgery for a cavernous angioma, presented with meningitis. Cerebrospinal fluid culture revealed a multidrug-resistant Pseudomonas aeruginosa, initially sensitive only to colistin. We successfully used intrathecal amikacin and intravenous cefepime continuous infusion plus intravenous amikacin after two previous ineffective therapeutic approaches. Conclusion: The evaluation of the antibiotic concentration and the bactericidal activity in cerebrospinal fluid may contribute to the choice of the drug in cases of multidrug-resistant meningitis.

Original languageEnglish
Pages (from-to)1369-1372
Number of pages4
JournalInfection and Drug Resistance
Volume11
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Amikacin
Meningitis
Pseudomonas aeruginosa
Cerebrospinal Fluid
Colistin
Cavernous Hemangioma
Intravenous Infusions
Therapeutics
Anti-Bacterial Agents
Equipment and Supplies
Pharmaceutical Preparations
cefepime

Keywords

  • Amikacin
  • Pan-resistant meningitis
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

@article{72e2f9155c7645979524fd24af666596,
title = "Efficacy of intraventricular amikacin treatment in pan-resistant pseudomonas aeruginosa postsurgical meningitis",
abstract = "Background: We describe a case of pan-resistant Pseudomonas aeruginosa postsurgical meningitis associated with the presence of an external ventricular device. We changed therapy twice; finally, by using amikacin and a continuous infusion of cefepime, we obtained clinical improvement. Case presentation: A female patient, who underwent surgery for a cavernous angioma, presented with meningitis. Cerebrospinal fluid culture revealed a multidrug-resistant Pseudomonas aeruginosa, initially sensitive only to colistin. We successfully used intrathecal amikacin and intravenous cefepime continuous infusion plus intravenous amikacin after two previous ineffective therapeutic approaches. Conclusion: The evaluation of the antibiotic concentration and the bactericidal activity in cerebrospinal fluid may contribute to the choice of the drug in cases of multidrug-resistant meningitis.",
keywords = "Amikacin, Pan-resistant meningitis, Pseudomonas aeruginosa",
author = "Mariadelfina Molinaro and Paola Morelli and {De Gregori}, Manuela and {De Gregori}, Simona and Ilaria Giardini and Federica Tordato and Vincenzina Monzillo and Daria Pocaterra and Erminia Casari",
year = "2018",
month = "1",
day = "1",
doi = "10.2147/IDR.S169271",
language = "English",
volume = "11",
pages = "1369--1372",
journal = "Infection and Drug Resistance",
issn = "1178-6973",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Efficacy of intraventricular amikacin treatment in pan-resistant pseudomonas aeruginosa postsurgical meningitis

AU - Molinaro, Mariadelfina

AU - Morelli, Paola

AU - De Gregori, Manuela

AU - De Gregori, Simona

AU - Giardini, Ilaria

AU - Tordato, Federica

AU - Monzillo, Vincenzina

AU - Pocaterra, Daria

AU - Casari, Erminia

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: We describe a case of pan-resistant Pseudomonas aeruginosa postsurgical meningitis associated with the presence of an external ventricular device. We changed therapy twice; finally, by using amikacin and a continuous infusion of cefepime, we obtained clinical improvement. Case presentation: A female patient, who underwent surgery for a cavernous angioma, presented with meningitis. Cerebrospinal fluid culture revealed a multidrug-resistant Pseudomonas aeruginosa, initially sensitive only to colistin. We successfully used intrathecal amikacin and intravenous cefepime continuous infusion plus intravenous amikacin after two previous ineffective therapeutic approaches. Conclusion: The evaluation of the antibiotic concentration and the bactericidal activity in cerebrospinal fluid may contribute to the choice of the drug in cases of multidrug-resistant meningitis.

AB - Background: We describe a case of pan-resistant Pseudomonas aeruginosa postsurgical meningitis associated with the presence of an external ventricular device. We changed therapy twice; finally, by using amikacin and a continuous infusion of cefepime, we obtained clinical improvement. Case presentation: A female patient, who underwent surgery for a cavernous angioma, presented with meningitis. Cerebrospinal fluid culture revealed a multidrug-resistant Pseudomonas aeruginosa, initially sensitive only to colistin. We successfully used intrathecal amikacin and intravenous cefepime continuous infusion plus intravenous amikacin after two previous ineffective therapeutic approaches. Conclusion: The evaluation of the antibiotic concentration and the bactericidal activity in cerebrospinal fluid may contribute to the choice of the drug in cases of multidrug-resistant meningitis.

KW - Amikacin

KW - Pan-resistant meningitis

KW - Pseudomonas aeruginosa

UR - http://www.scopus.com/inward/record.url?scp=85057765570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057765570&partnerID=8YFLogxK

U2 - 10.2147/IDR.S169271

DO - 10.2147/IDR.S169271

M3 - Article

VL - 11

SP - 1369

EP - 1372

JO - Infection and Drug Resistance

JF - Infection and Drug Resistance

SN - 1178-6973

ER -