Abstract
Background: We describe a case of pan-resistant Pseudomonas aeruginosa postsurgical meningitis associated with the presence of an external ventricular device. We changed therapy twice; finally, by using amikacin and a continuous infusion of cefepime, we obtained clinical improvement. Case presentation: A female patient, who underwent surgery for a cavernous angioma, presented with meningitis. Cerebrospinal fluid culture revealed a multidrug-resistant Pseudomonas aeruginosa, initially sensitive only to colistin. We successfully used intrathecal amikacin and intravenous cefepime continuous infusion plus intravenous amikacin after two previous ineffective therapeutic approaches. Conclusion: The evaluation of the antibiotic concentration and the bactericidal activity in cerebrospinal fluid may contribute to the choice of the drug in cases of multidrug-resistant meningitis.
| Original language | English |
|---|---|
| Pages (from-to) | 1369-1372 |
| Number of pages | 4 |
| Journal | Infection and Drug Resistance |
| Volume | 11 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
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Keywords
- Amikacin
- Pan-resistant meningitis
- Pseudomonas aeruginosa
ASJC Scopus subject areas
- Pharmacology
- Infectious Diseases
- Pharmacology (medical)
Cite this
Efficacy of intraventricular amikacin treatment in pan-resistant pseudomonas aeruginosa postsurgical meningitis. / Molinaro, Mariadelfina; Morelli, Paola; De Gregori, Manuela; De Gregori, Simona; Giardini, Ilaria; Tordato, Federica; Monzillo, Vincenzina; Pocaterra, Daria; Casari, Erminia.
In: Infection and Drug Resistance, Vol. 11, 01.01.2018, p. 1369-1372.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy of intraventricular amikacin treatment in pan-resistant pseudomonas aeruginosa postsurgical meningitis
AU - Molinaro, Mariadelfina
AU - Morelli, Paola
AU - De Gregori, Manuela
AU - De Gregori, Simona
AU - Giardini, Ilaria
AU - Tordato, Federica
AU - Monzillo, Vincenzina
AU - Pocaterra, Daria
AU - Casari, Erminia
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: We describe a case of pan-resistant Pseudomonas aeruginosa postsurgical meningitis associated with the presence of an external ventricular device. We changed therapy twice; finally, by using amikacin and a continuous infusion of cefepime, we obtained clinical improvement. Case presentation: A female patient, who underwent surgery for a cavernous angioma, presented with meningitis. Cerebrospinal fluid culture revealed a multidrug-resistant Pseudomonas aeruginosa, initially sensitive only to colistin. We successfully used intrathecal amikacin and intravenous cefepime continuous infusion plus intravenous amikacin after two previous ineffective therapeutic approaches. Conclusion: The evaluation of the antibiotic concentration and the bactericidal activity in cerebrospinal fluid may contribute to the choice of the drug in cases of multidrug-resistant meningitis.
AB - Background: We describe a case of pan-resistant Pseudomonas aeruginosa postsurgical meningitis associated with the presence of an external ventricular device. We changed therapy twice; finally, by using amikacin and a continuous infusion of cefepime, we obtained clinical improvement. Case presentation: A female patient, who underwent surgery for a cavernous angioma, presented with meningitis. Cerebrospinal fluid culture revealed a multidrug-resistant Pseudomonas aeruginosa, initially sensitive only to colistin. We successfully used intrathecal amikacin and intravenous cefepime continuous infusion plus intravenous amikacin after two previous ineffective therapeutic approaches. Conclusion: The evaluation of the antibiotic concentration and the bactericidal activity in cerebrospinal fluid may contribute to the choice of the drug in cases of multidrug-resistant meningitis.
KW - Amikacin
KW - Pan-resistant meningitis
KW - Pseudomonas aeruginosa
UR - http://www.scopus.com/inward/record.url?scp=85057765570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057765570&partnerID=8YFLogxK
U2 - 10.2147/IDR.S169271
DO - 10.2147/IDR.S169271
M3 - Article
VL - 11
SP - 1369
EP - 1372
JO - Infection and Drug Resistance
JF - Infection and Drug Resistance
SN - 1178-6973
ER -