Efficacy of ivermectin to control Strongyloides stercoralis infection in sheltered dogs

Paola Paradies, Dora Buonfrate, Roberta Iatta, Fabrizio Iarussi, Giovanni Giorli, Vincenzo Ostilio Palmieri, Mariateresa Sasanelli, Francesca Perandin, Jan Šlapeta, Antonio Capogna, Domenico Otranto, Zeno Bisoffi

Research output: Contribution to journalArticlepeer-review


In dogs, information on treatments against S. stercoralis infection is rare and anecdotal. The aim of the present work was to evaluate the treatment outcome of S. stercoralis natural infection in sheltered dogs. Furthermore, based on the potential risk of infection, people working in the infected shelter were also tested. Seventeen sheltered dogs positive to S. stercoralis using the Baermann test were treated with ivermectin 200 μg/kg/sid/os for two consecutive days. Only two dogs showed clinical signs suggestive of strongyloidiasis (diarrhea, weigh loss) at diagnosis. All dogs showed consistently negative results for S. stercoralis at weekly monitoring after treatment using both the direct microscopy and Baermann test. Real-time PCR confirmed negative results at the last follow up 2 months after treatment. Serology performed at the first diagnosis showed that 82% and 41% of dogs were positive for S. stercoralis using an IFAT (titres ranging from 1:40 to 1:320) and ELISA, respectively. Two months after treatment, IFAT titres were strongly reduced in all animals. The results of clinical pathological laboratory tests at diagnosis in the positive dogs were within normal ranges, except for the two symptomatic dogs. Serum collected from two out of 14 shelter workers tested positive with titres 1:20 and 1:40 for S. stercoralis using an IFAT. Results of the study confirm that ivermectin was an effective treatment option to control S. stercoralis infection in dogs. Shelter workers are at risk of infection with S. stercoralis, thus the application of correct deworming protocols to reduce the environmental infective larval burden is essential to protect dogs and probably also shelter workers from the risk of infection.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalActa Tropica
Publication statusPublished - Feb 2019


  • Clinical-pathological laboratory alterations
  • Faecal monitoring
  • Serology
  • Shelter
  • Strongyloides stercoralis
  • Treatment

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases


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